Volume 7 , Issue 3 , September 2019 , Pages: 117 - 124
High Expression of C-reactive Protein Increases the Risk of Poor Prognosis in Patients with Gastric Cancer: A Meta-analysis
Fulun Li, Department of Child Development and Behavior, Children’s Hospital of Gansu Province/Lanzhou University Second Hospital, Lanzhou, China
Ke Liu, School of Applied Chemical Engineering, Lanzhou Petrochemical Polytechnic, Lanzhou, China
Qianlong Zhao, Department of Child Development and Behavior, Children’s Hospital of Gansu Province/Lanzhou University Second Hospital, Lanzhou, China
Junyi Chen, Department of Child Development and Behavior, Children’s Hospital of Gansu Province/Lanzhou University Second Hospital, Lanzhou, China
Lingfei Liu, School of Public Health, Lanzhou University, Laanzhou, China
Qing-Mu Xie, Department of Psychology, Tohoku University, Sendai, Japan
Jing Yang, Department of Child Development and Behavior, Children’s Hospital of Gansu Province/Lanzhou University Second Hospital, Lanzhou, China
Received: Aug. 27, 2019;       Accepted: Sep. 10, 2019;       Published: Sep. 24, 2019
DOI: 10.11648/j.crj.20190703.16        View        Downloads  
There are many researches on the correlation between C-reactive protein (CRP) and prognosis of gastric cancer, but whether CRP could be used as an evaluation indicator for prognosis of gastric cancer patients, which was still controversial. Therefore, we conducted meta-analysis based on 18 studies involving 3656 objects. The results show that, CRP was significantly correlated with the risk of poor prognosis of gastric cancer patients [HR (95%CI) 1.50 (1.24, 1.81) P=0.000], and the risk of the poor prognosis can be significantly increased when CRP>10mg/L. In the different clinical stage, high expression of CRP can increases the risk of poor prognosis. The CRP can be used as an important indicator of poor prognosis of gastric cancer patients.
C-reactive Protein, Gastric Cancer, Prognosis, Meta-analysis
To cite this article
Fulun Li, Ke Liu, Qianlong Zhao, Junyi Chen, Lingfei Liu, Qing-Mu Xie, Jing Yang, High Expression of C-reactive Protein Increases the Risk of Poor Prognosis in Patients with Gastric Cancer: A Meta-analysis, Cancer Research Journal. Vol. 7, No. 3, 2019, pp. 117-124. doi: 10.11648/j.crj.20190703.16
Copyright © 2019 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
[ 1 ]
Parkin DM, Pisani P, et al. Global cancer statistics. CA; a cancer journal for clinicians. 2005; 55; 74-108.
[ 2 ]
Yang HP, Zhang CQ. Research progress in gene therapy of gastric cancer. Journal of Modern Oncology. 2008; 16 (6); 1058-61.
[ 3 ]
Rossomando AJ, Sanghera JS, et al. Biochemical characterization of a family of serine/threonine protein kinases regulated by tyrosine and serine/threonine phosphorylations. Journal of Biological Chemistry. 1991; 266 (30); 20270-5.
[ 4 ]
Zhang Yj, Zhu ZY, et al. Study on relationship of C-reactive protein with peritoneal cavity metastasis and prognosis of gastric carcinoma. Chinese Clinical Oncology. 2015; 20 (6); 535-9.
[ 5 ]
Roxburgh CS, Mcmillan DC. Role of systemic inflammatory response in predicting survival in patients with primary operable cancer. Future Oncology. 2010; 6 (1); 149-63.
[ 6 ]
Baba H, Kuwabara K, et al. C-reactive protein as a significant prognostic factor for stage IV gastric cancer patients. Anticancer Research. 2013; 33 (12); 5591-5.
[ 7 ]
Aizawa M, Gotohda N, et al. Predictive Value of Baseline Neutrophil/Lymphocyte Ratio for T4 Disease in Wall-Penetrating Gastric Cancer. World Journal of Surgery. 2011; 35 (12); 2717-22.
[ 8 ]
Fujitani K, Yamada M, et al. Optimal indications of surgical palliation for incurable advanced gastric cancer presenting with malignant gastrointestinal obstruction. Gastric Cancer Official Journal of the International Gastric Cancer Association & the Japanese Gastric Cancer Association. 2011; 14 (4); 353-9.
[ 9 ]
Albanopoulos K, Alevizos L, et al. C-reactive protein, white blood cells, and neutrophils as early predictors of postoperative complications in patients undergoing laparoscopic sleeve gastrectomy. Surgical Endoscopy. 2012; 27 (3); 864-71.
[ 10 ]
Chang CC, Sun CF, et al. Preoperative serum C-reactive protein and gastric cancer; Clinical-pathological correlation and prognostic significance. Chang Gung Medical Journal. 2010; 33 (3); 301-12.
[ 11 ]
Hashimoto K, Takashima A, et al. Progression-free survival in first-line chemotherapy is a prognostic factor in second-line chemotherapy in patients with advanced gastric cancer. Journal of Cancer Research & Clinical Oncology. 2010; 136 (7); 1059-64.
[ 12 ]
Hwang JE, Kim HN, et al. Prognostic significance of a systemic inflammatory response in patients receiving first-line palliative chemotherapy for recurred or metastatic gastric cancer. Bmc Cancer. 2011; 11 (1); 1-7.
[ 13 ]
Ishino Y, Saigusa S, et al. Preoperative C-reactive protein and operative blood loss predict poor prognosis in patients with gastric cancer after laparoscopy-assisted gastrectomy. Asian Journal of Endoscopic Surgery. 2014; 7 (4); 287-94.
[ 14 ]
Iwasa S, Nakajima TE, et al. Systemic chemotherapy for peritoneal disseminated gastric cancer with inadequate oral intake; a retrospective study. International Journal of Clinical Oncology. 2011; 16 (1); 57-62.
[ 15 ]
Jeong J, Lim SM, et al. Comparison of two inflammation-based prognostic scores in patients with unresectable advanced gastric cancer. Oncology. 2012; 83 (5); 292-9.
[ 16 ]
Kwon HC, Kim SH, et al. Clinicopathologic significance of expression of nuclear factor-kB RelA and its target gene products in gastric cancer patients. World Journal of Gastroenterology. 2012; 18 (34); 4744-50.
[ 17 ]
Mohri Y, Miki C. Reply; Prognostic Significance of Host- and Tumor-related Factors in Patients with Gastric Cancer. World Journal of Surgery. 2010; 34 (2); 285-90.
[ 18 ]
Nozoe T, Iguchi T, et al. Preoperative elevation of serum C-reactive protein as an independent prognostic indicator for gastric cancer. Surgery Today. 2011; 41 (4); 510-3.
[ 19 ]
Takuro Saito MD, FACS YKM, et al. Which is a more reliable indicator of survival after gastric cancer surgery; Postoperative complication occurrence or C-reactive protein elevation? Journal of Surgical Oncology. 2015; 112 (8); 894–9.
[ 20 ]
Shimura T, Kitagawa M, et al. C-reactive protein is a potential prognostic factor for metastatic gastric cancer. Anticancer Research. 2012; 32 (2); 491-496.
[ 21 ]
Wang DS, Ren C, et al. Comparison of the prognostic value of various preoperative inflammation-based factors in patients with stage III gastric cancer. Tumor Biology. 2012; 8 (33); 749-56.
[ 22 ]
Zhu M, Wei J, et al. Correlation between serum c-reactive protein level and prognosis of advanced gastric cancer. Guizhou Medical Journal. 2016; 40 (3); 249-50.
[ 23 ]
Yamashita H, Katai H. Systemic Inflammatory Response in Gastric Cancer. World Journal of Surgery. 2010; 34 (10); 2399-400.
[ 24 ]
Groblewska M, Mroczko B, et al. Interleukin 6 and C-reactive protein in esophageal cancer. Clinica Chimica Acta. 2012; 413 (19-20); 1583-90.
[ 25 ]
Kwon KA, Kim SH, et al. Clinical significance of preoperative serum vascular endothelial growth factor, interleukin-6, and C-reactive protein level in colorectal cancer. Bmc Cancer. 2010; 10 (10); 203-06.
[ 26 ]
Rielland M, Cantor DJ, et al. Senescence-associated SIN3B promotes inflammation and pancreatic cancer progression. Journal of Clinical Investigation. 2014; 124 (5); 2125-35.
[ 27 ]
Hasselbalch HC. Perspectives on chronic inflammation in essential thrombocythemia, polycythemia vera, and myelofibrosis; is chronic inflammation a trigger and driver of clonal evolution and development of accelerated atherosclerosis and second cancer? Blood. 2012; 119 (14); 3219-25.
[ 28 ]
Yu Q, Yu XF, et al. Prognostic role of C-reactive protein in gastric cancer; a meta-analysis. Asian Pacific Journal of Cancer Prevention Apjcp. 2013; 14 (10); 5735-40.
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