Volume 9, Issue 1, March 2021, Page: 14-22
Ewing Sarcoma/Peripheral Neuroectodermal Tumor of Bone and Soft Tissue in Infants: A Report from Children Cancer Hospital of Egypt
Enas El Nadi, Department of Clinical Oncology, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt; Pediatric Oncology Department, Children Cancer Hospital of Egypt, Cairo, Egypt
Ahmed El Ghoneimy, Orthopedics, Children Cancer Hospital of Egypt, Cairo, Egypt
Maged El Shafiey, Surgical Oncology, Children Cancer Hospital of Egypt, Cairo, Egypt; Surgical Oncology National Cancer Institute, Cairo, Egypt
Hala Taha, Surgical Pathology, Children Cancer Hospital of Egypt, Cairo, Egypt; Surgical Pathology National Cancer Institute, Cairo, Egypt
Mohamed Saad Zaghlool, Radiotherapy Department, Children Cancer Hospital of Egypt, Cairo, Egypt; Radiotherapy Department, National Cancer Institute, Cairo, Egypt
Iman Zaki, Radiology Department, Children Cancer Hospital of Egypt, Cairo, Egypt; Radiology Department, National Cancer Institute, Cairo, Egypt
Nehal Kamal, Clinical Research Department, Children Cancer Hospital of Egypt, Cairo, Egypt
Nada Mounir, Department of Clinical Oncology, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt; Pediatric Oncology Department, National Cancer Institute, Cairo, Egypt
Manal Amin, Pediatric Oncology Department, Children Cancer Hospital of Egypt, Cairo, Egypt; Orthopedics, Children Cancer Hospital of Egypt, Cairo, Egypt
Received: Dec. 22, 2020;       Accepted: Jan. 11, 2021;       Published: Jan. 25, 2021
DOI: 10.11648/j.crj.20210901.13       View        Downloads  
Abstract
Introduction: Ewing sarcoma is an aggressive malignancy of bone and soft tissue. It is rare in children under age 5years. Ewing's sarcoma family tumors include classic Ewing’s sarcoma, primitive neuroectodermal tumour and Askin tumor ES is the second most common variety of primary bone cancer in adolescents and young adults. The treatment strategy for ES is characterized by multi-disciplinary collaboration between pediatric oncologists, medical oncologists, radiation oncologists, and orthopedic surgeons. Although the survival rate of ES patients has improved, their prognosis remains unsatisfactory, and the treatment of ES is still challenging specially in age group below 3 years. Patients and methods: A Retrospective study of children below 3 years with a diagnosis Ewing Sarcoma/PNET treated at our CCHE from July 2009 till December 2018. Results: A review of 46 patients with age ranged from 3 months to 3 years, Mean of age was 1.8. Primary site was Osseous and extraosseus in 23 infant patients for each. Main site was mainly axial in 28 cases (60.8%). Cases were treated according to COG protocol. Infantile Ewing sarcoma OS and EFS at 5-years OS were 75.5% and 66.7%. Conclusion: Patients below 3 years represent an unusually young age group. Conclusion: ES/PNET in age below 3 years is a unique age group with a different management and outcome.
Keywords
Ewing Sarcoma, Survival, Infants
To cite this article
Enas El Nadi, Ahmed El Ghoneimy, Maged El Shafiey, Hala Taha, Mohamed Saad Zaghlool, Iman Zaki, Nehal Kamal, Nada Mounir, Manal Amin, Ewing Sarcoma/Peripheral Neuroectodermal Tumor of Bone and Soft Tissue in Infants: A Report from Children Cancer Hospital of Egypt, Cancer Research Journal. Vol. 9, No. 1, 2021, pp. 14-22. doi: 10.11648/j.crj.20210901.13
Copyright
Copyright © 2021 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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