Volume 9 , Issue 2 , June 2021 , Pages: 106 - 110
Expression of HER2 in Gastric Carcinoma According to Tumor Location
Monoar Hossain, Department of Surgery, Khulna Medical College, Khulna, Bangladesh
Miranur Rahman, National Institute of Cancer Research & Hospital (NICRH), Dhaka, Bangladesh
Mohammad Sahajadul Alam, Department of Surgical Oncology, National Institute of Cancer Research & Hospital (NICRH), Dhaka, Bangladesh
Monzurul Islam, Department of Surgical Oncology, National Institute of Cancer Research & Hospital (NICRH), Dhaka, Bangladesh
Received: Apr. 22, 2021;       Accepted: May 31, 2021;       Published: Jun. 7, 2021
DOI: 10.11648/j.crj.20210902.14        View        Downloads  
Abstract
Introduction: HER2/neu (c-erbB-2) is an oncogene that encodes a transmembrane glycoprotein with tyrosine kinase activity known as 185 kDa. This 185 kDa belongs to the epidermal growth factor receptor. Though HER-2 expression has been extensively found in advanced gastric cancer, few recent studies have evaluated the same in early gastric cancers. HER-2 overexpression is considered one of the poorest prognostic variables after nodal status in early gastric cancers too. Aim of the study: To find out the expression of HER2 in gastric carcinoma according to tumor location. Material & Methods: This cross-sectional study was conducted in the Department of Surgical Oncology of National Institute of Cancer, Research and Hospital, Mohakhali, Dhaka. The study period was from March 2014 to April 2015. A total of 80 patients were included in the study. After receiving the gastrectomy specimen, it was fixed in 10% formaldehyde. Statistical analysis was carried out using a computer-based software package for social science (SPSS 16.1). Ethical clearance was taken from the ethical committee of NICRH. Results: The highest patients were from the 61-70 years age group and the lowest were from 71-80 years. The mean age of the patients was 59.71 (±10.19) years. The female to male ratio in this study was 1: 2.48. The leading number of patients presented with abdominal pain where the vague abdominal discomfort was also included. They were 75%. This clinical condition was followed by vomiting which coined 58.75% of respondents. Out of 80 patients, 27 (33.75%) patients bore A +ve blood group whereas 23 (28.75%) patients had B+ve blood group. Most of the tumors were located in the distal (Noncardiac) part of the stomach (75%). Regarding staging 79 (98.75%) patients were in the advanced stage of the disease. Most of the tumors were located in the distal part of the stomach (11.67%). Conclusion: We reported a 12.5% of positive HER2 expression (IHC=3+ & 2+) in a series of 80 surgical specimens of gastric cancer patients. We also observed that positive HER2 expression varied depending on the histology and the primary tumor localization.
Keywords
Expression, HER2/neu, Gastric Carcinoma, Tumor, Growth Factor
To cite this article
Monoar Hossain, Miranur Rahman, Mohammad Sahajadul Alam, Monzurul Islam, Expression of HER2 in Gastric Carcinoma According to Tumor Location, Cancer Research Journal. Vol. 9, No. 2, 2021, pp. 106-110. doi: 10.11648/j.crj.20210902.14
Copyright
Copyright © 2021 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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