Epidemiological, Clinical, Diagnostical and Histopathological Aspects of Medular Compressions of Metastatic Origin

Jean Paul Engbang; Mathieu Motah; Basile Essola; Landry Metso

doi:doi:10.11648/j.crj.20210901.15

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Epidemiological, Clinical, Diagnostical and Histopathological Aspects of Medular Compressions of Metastatic Origin

Jean Paul Engbang, Mathieu Motah, Basile Essola, Landry Metso

Published in Cancer Research Journal (Volume 9, Issue 1)

Received: 26 January 2021 Accepted: 3 February 2021 Published: 10 February 2021

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Abstract

Background: according to the World Health Organization (WHO) in 2019, cancer metastasis constitutes a fast proliferation of abnormal cells which spread to other organs. Bone is the third most targeted organ behind the lungs and the liver, and the most frequent bone’s localizations are; the spine, pelvic bone and the ribs. Metastatic spinal compressions constitutes, a well-defined clinical entity of which the prevalence and incidence depends on the primitive tumor, Objective: To study the epidemiological, clinical, diagnosis and the histopathologic aspect of spinal cord metastatic compressions. Patients and method: It was a retrospective descriptive study over a period 10 years in the Douala General and Laquintinie Hospitals. We included in our study patients with slow spinal compression since January 1st 2010 to December 31st 2019. We included in our study, filled patients medical reports suffering of a primitive tumor which spread to the spine, with pathological and radiological evidence. Results: we recruited a total of 125 patients of which 68% where male and 32% female with a sex-ratio of 2.12, the mean age was 55.8 ± 15.397. The most frequent spine localization of metastasis was the lumbar region 57.1%. The spine pain was the main symptom seen in 98.4% associated to radicular nerf pain in 33.6%, sensibility and motor dysfunctions represented 94% and 92% respectively, and urinary dysfunction represented 44.8%. The diagnosis was essentially based on spine X-rays and was being realized in 64.8% of cases. Lytic lesions and bone condensation were the main abnormalities viewed with 22.4%. The second group of imaging was the CT-Scan and MRI done in 62.4%. The most represented primitive tumor was the prostate cancer 59 cases (47.25%) with adenocarcinoma as the main histological type 56 cases. Breast cancer came next with 32 cases (25.6%), invasive ductal carcinoma as the most represented histological type 26 cases (20.6%). The lung cancer came at the third position with 7 cases (10.4%) with the small cell carcinoma been the most represented histological type with 4.8%. Conclusion: spinal cord compression of metastatic origin is a frequent pathology in patients with osteophilic tumor, despite adequate measures, the prognosis remains unresolved. Emphasis should be placed on raising awareness of different early diagnostic measures.

Published in	Cancer Research Journal (Volume 9, Issue 1)
DOI	10.11648/j.crj.20210901.15
Page(s)	34-40
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Spinal Metastasis, Spinal Cord Compression, Emergency

References

[1]	Ferlay J, Soerjomataram, Ervik M, Dikshit R, Eser R MC et al. GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality worldwide : IARC CancerBase No. 11 Lyon, France: International Agency for Research on Cancer. Int J Cancer. 2015; 136 (5): E359–86.
[2]	Samlali A, Bouchbika Z, Bennani W, Taleb A et al Brain metastasis from rectal adenocarcinoma: about a case and review of the literature. 2017; 26: 58
[3]	Camins MB, Jenkins AL, Singhal A PR. Tumor of vertebral axis: Begnin, primary malignant, and metastatic tumor. 5th ed Philadelphia WB Saunders Co. 2004; 4835–68.
[4]	Dennis D, Dominguez E, Lauper N, Velastegui A, Reynolds J. Métastases de la colonne vertébrale : indications au traitement chirurgical. Rev Med suisse. 2016; 12: 2168–71.
[5]	M. Gremaud D, Delouche C Mo. Traitement des métastases osseuses par les biphosphonates. Rev Med suisse. 2006; 2: 31127.
[6]	Domchek SM, Younger j, Finkelstein DM SM. Predictor of skeletal complications in patients with metastatic breast carcinoma. Cancer. 2000; 89: 363–8.
[7]	R. karim, T. El Hamdani, A. Maati, T. Mesbahi AC et al. Prise en charge des métastases rachidiennes. Masson SAS. 2013; 59: 263.
[8]	Agarwall J, Baum P. critères pour la palliation des métastases osseuses. IAEA. 2008; 12–4.
[9]	Hamaoka T, Madewell, Podoloff DA. Bone imaging in breast cancer. JClinOncol. 2004; 22: 2942–53.
[10]	Dur H, Janson V. Differenzierte Therapie metastatischer läsionen des knochens. arthritis und Rheuma. 2007; 3: 163–8.
[11]	Lipton A. New approaches to trating and preventing bone metastases. Curr Opin Support Palliat Care. 2010; 26 (4): 178–81.
[12]	Matsuyama Y. al E. surgical results of intramedullary spinal cord tumor with spinal cord monitorring to guide extent of resection. J. neurosurg spine. 2009; 10 (5): 404–13.
[13]	Chamberlain M. Kormanik. epidural spinal cord compression a single institution’s retrospective experience. Neuro Oncol. 1990; 120–3
[14]	Djiencheu, Njamnshi, Ngandeu, al E. compressions médullaires lentes d’origines tumorale et pseudo-tumorale à yaounde. AFJ neurol sci. 2007; 26: 15–21.
[15]	Kone I. prise en charge des tumeurs vertébro-médullaires dans le service de neurochirurgie du CHU de Gabriel Toure. bibliosante. 2011; 21.
[16]	Zileli M, Coll. Primary tumors of the cervical spine: a retrospective review of 35 surgically managed cases. spine J. 2007; 7 (2): 165–73
[17]	Ismail Y. prise en charge des compressions médullaires d’origine tumorale. Fac médécine Marrakech. 2016; 35: 44
[18]	Ongolo-Zogo, Djientcheu, Njamnshi, Lekoubou, Eloundou, Gonsu. contribution de l’imagerie médicale dans le diagnostic étiologique des compressions lentes au Cameroun. J Afr Imag Med. 2006; 1: 25–34
[19]	Wahab A abd el, Soufyane A, Djalel B. Métastases vertébrales. Fac Med TLEMCEN. 2017; 39
[20]	Diomande M, Nseng-Nseng R ingrid, Kouame-Assouan A eric, All E. compresions médullaires lentes : prévalence et étiologie. Rev marocaine Rhumatol. 2015; 33: 27–30
[21]	Kassegne, Sakiye, Kanossoua, Al E. prise en charge des compressions médullaires lentes au Togo. Med sante Trop. 2013; 23: 206–10
[22]	Joe C. Ramendi P. Metastic epidural spinal cord compression. Lancet Neurol. 2008; 7 (5): 459–66.
[23]	Sinardet D, Chabane A, Khalil T, Seigneuret E. Resultats neurologiques de 152 patients chirurgicaux atteints de métastases vertébrales. PubMed. 2000; 46 (1): 4–10.

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APA Style

Jean Paul Engbang, Mathieu Motah, Basile Essola, Landry Metso. (2021). Epidemiological, Clinical, Diagnostical and Histopathological Aspects of Medular Compressions of Metastatic Origin. Cancer Research Journal, 9(1), 34-40. https://doi.org/10.11648/j.crj.20210901.15

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ACS Style

Jean Paul Engbang; Mathieu Motah; Basile Essola; Landry Metso. Epidemiological, Clinical, Diagnostical and Histopathological Aspects of Medular Compressions of Metastatic Origin. Cancer Res. J. 2021, 9(1), 34-40. doi: 10.11648/j.crj.20210901.15

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AMA Style

Jean Paul Engbang, Mathieu Motah, Basile Essola, Landry Metso. Epidemiological, Clinical, Diagnostical and Histopathological Aspects of Medular Compressions of Metastatic Origin. Cancer Res J. 2021;9(1):34-40. doi: 10.11648/j.crj.20210901.15

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@article{10.11648/j.crj.20210901.15,
  author = {Jean Paul Engbang and Mathieu Motah and Basile Essola and Landry Metso},
  title = {Epidemiological, Clinical, Diagnostical and Histopathological Aspects of Medular Compressions of Metastatic Origin},
  journal = {Cancer Research Journal},
  volume = {9},
  number = {1},
  pages = {34-40},
  doi = {10.11648/j.crj.20210901.15},
  url = {https://doi.org/10.11648/j.crj.20210901.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20210901.15},
  abstract = {Background: according to the World Health Organization (WHO) in 2019, cancer metastasis constitutes a fast proliferation of abnormal cells which spread to other organs. Bone is the third most targeted organ behind the lungs and the liver, and the most frequent bone’s localizations are; the spine, pelvic bone and the ribs. Metastatic spinal compressions constitutes, a well-defined clinical entity of which the prevalence and incidence depends on the primitive tumor, Objective: To study the epidemiological, clinical, diagnosis and the histopathologic aspect of spinal cord metastatic compressions. Patients and method: It was a retrospective descriptive study over a period 10 years in the Douala General and Laquintinie Hospitals. We included in our study patients with slow spinal compression since January 1st 2010 to December 31st 2019. We included in our study, filled patients medical reports suffering of a primitive tumor which spread to the spine, with pathological and radiological evidence. Results: we recruited a total of 125 patients of which 68% where male and 32% female with a sex-ratio of 2.12, the mean age was 55.8 ± 15.397. The most frequent spine localization of metastasis was the lumbar region 57.1%. The spine pain was the main symptom seen in 98.4% associated to radicular nerf pain in 33.6%, sensibility and motor dysfunctions represented 94% and 92% respectively, and urinary dysfunction represented 44.8%. The diagnosis was essentially based on spine X-rays and was being realized in 64.8% of cases. Lytic lesions and bone condensation were the main abnormalities viewed with 22.4%. The second group of imaging was the CT-Scan and MRI done in 62.4%. The most represented primitive tumor was the prostate cancer 59 cases (47.25%) with adenocarcinoma as the main histological type 56 cases. Breast cancer came next with 32 cases (25.6%), invasive ductal carcinoma as the most represented histological type 26 cases (20.6%). The lung cancer came at the third position with 7 cases (10.4%) with the small cell carcinoma been the most represented histological type with 4.8%. Conclusion: spinal cord compression of metastatic origin is a frequent pathology in patients with osteophilic tumor, despite adequate measures, the prognosis remains unresolved. Emphasis should be placed on raising awareness of different early diagnostic measures.},
 year = {2021}
}

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TY - JOUR
T1 - Epidemiological, Clinical, Diagnostical and Histopathological Aspects of Medular Compressions of Metastatic Origin
AU - Jean Paul Engbang
AU - Mathieu Motah
AU - Basile Essola
AU - Landry Metso
Y1 - 2021/02/10
PY - 2021
N1 - https://doi.org/10.11648/j.crj.20210901.15
DO - 10.11648/j.crj.20210901.15
T2 - Cancer Research Journal
JF - Cancer Research Journal
JO - Cancer Research Journal
SP - 34
EP - 40
PB - Science Publishing Group
SN - 2330-8214
UR - https://doi.org/10.11648/j.crj.20210901.15
AB - Background: according to the World Health Organization (WHO) in 2019, cancer metastasis constitutes a fast proliferation of abnormal cells which spread to other organs. Bone is the third most targeted organ behind the lungs and the liver, and the most frequent bone’s localizations are; the spine, pelvic bone and the ribs. Metastatic spinal compressions constitutes, a well-defined clinical entity of which the prevalence and incidence depends on the primitive tumor, Objective: To study the epidemiological, clinical, diagnosis and the histopathologic aspect of spinal cord metastatic compressions. Patients and method: It was a retrospective descriptive study over a period 10 years in the Douala General and Laquintinie Hospitals. We included in our study patients with slow spinal compression since January 1st 2010 to December 31st 2019. We included in our study, filled patients medical reports suffering of a primitive tumor which spread to the spine, with pathological and radiological evidence. Results: we recruited a total of 125 patients of which 68% where male and 32% female with a sex-ratio of 2.12, the mean age was 55.8 ± 15.397. The most frequent spine localization of metastasis was the lumbar region 57.1%. The spine pain was the main symptom seen in 98.4% associated to radicular nerf pain in 33.6%, sensibility and motor dysfunctions represented 94% and 92% respectively, and urinary dysfunction represented 44.8%. The diagnosis was essentially based on spine X-rays and was being realized in 64.8% of cases. Lytic lesions and bone condensation were the main abnormalities viewed with 22.4%. The second group of imaging was the CT-Scan and MRI done in 62.4%. The most represented primitive tumor was the prostate cancer 59 cases (47.25%) with adenocarcinoma as the main histological type 56 cases. Breast cancer came next with 32 cases (25.6%), invasive ductal carcinoma as the most represented histological type 26 cases (20.6%). The lung cancer came at the third position with 7 cases (10.4%) with the small cell carcinoma been the most represented histological type with 4.8%. Conclusion: spinal cord compression of metastatic origin is a frequent pathology in patients with osteophilic tumor, despite adequate measures, the prognosis remains unresolved. Emphasis should be placed on raising awareness of different early diagnostic measures.
VL - 9
IS - 1
ER -

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Author Information

Jean Paul Engbang

Faculty of Medicine and Pharmaceutical Sciences, The University of Douala, Douala, Cameroun
Mathieu Motah

Faculty of Medicine and Pharmaceutical Sciences, The University of Douala, Douala, Cameroun
Basile Essola

Faculty of Medicine and Pharmaceutical Sciences, The University of Douala, Douala, Cameroun
Landry Metso

Faculty of Medicine and Pharmaceutical Sciences, The University of Douala, Douala, Cameroun

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APA Style

Jean Paul Engbang, Mathieu Motah, Basile Essola, Landry Metso. (2021). Epidemiological, Clinical, Diagnostical and Histopathological Aspects of Medular Compressions of Metastatic Origin. Cancer Research Journal, 9(1), 34-40. https://doi.org/10.11648/j.crj.20210901.15

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ACS Style

Jean Paul Engbang; Mathieu Motah; Basile Essola; Landry Metso. Epidemiological, Clinical, Diagnostical and Histopathological Aspects of Medular Compressions of Metastatic Origin. Cancer Res. J. 2021, 9(1), 34-40. doi: 10.11648/j.crj.20210901.15

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AMA Style

Jean Paul Engbang, Mathieu Motah, Basile Essola, Landry Metso. Epidemiological, Clinical, Diagnostical and Histopathological Aspects of Medular Compressions of Metastatic Origin. Cancer Res J. 2021;9(1):34-40. doi: 10.11648/j.crj.20210901.15

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@article{10.11648/j.crj.20210901.15,
  author = {Jean Paul Engbang and Mathieu Motah and Basile Essola and Landry Metso},
  title = {Epidemiological, Clinical, Diagnostical and Histopathological Aspects of Medular Compressions of Metastatic Origin},
  journal = {Cancer Research Journal},
  volume = {9},
  number = {1},
  pages = {34-40},
  doi = {10.11648/j.crj.20210901.15},
  url = {https://doi.org/10.11648/j.crj.20210901.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20210901.15},
  abstract = {Background: according to the World Health Organization (WHO) in 2019, cancer metastasis constitutes a fast proliferation of abnormal cells which spread to other organs. Bone is the third most targeted organ behind the lungs and the liver, and the most frequent bone’s localizations are; the spine, pelvic bone and the ribs. Metastatic spinal compressions constitutes, a well-defined clinical entity of which the prevalence and incidence depends on the primitive tumor, Objective: To study the epidemiological, clinical, diagnosis and the histopathologic aspect of spinal cord metastatic compressions. Patients and method: It was a retrospective descriptive study over a period 10 years in the Douala General and Laquintinie Hospitals. We included in our study patients with slow spinal compression since January 1st 2010 to December 31st 2019. We included in our study, filled patients medical reports suffering of a primitive tumor which spread to the spine, with pathological and radiological evidence. Results: we recruited a total of 125 patients of which 68% where male and 32% female with a sex-ratio of 2.12, the mean age was 55.8 ± 15.397. The most frequent spine localization of metastasis was the lumbar region 57.1%. The spine pain was the main symptom seen in 98.4% associated to radicular nerf pain in 33.6%, sensibility and motor dysfunctions represented 94% and 92% respectively, and urinary dysfunction represented 44.8%. The diagnosis was essentially based on spine X-rays and was being realized in 64.8% of cases. Lytic lesions and bone condensation were the main abnormalities viewed with 22.4%. The second group of imaging was the CT-Scan and MRI done in 62.4%. The most represented primitive tumor was the prostate cancer 59 cases (47.25%) with adenocarcinoma as the main histological type 56 cases. Breast cancer came next with 32 cases (25.6%), invasive ductal carcinoma as the most represented histological type 26 cases (20.6%). The lung cancer came at the third position with 7 cases (10.4%) with the small cell carcinoma been the most represented histological type with 4.8%. Conclusion: spinal cord compression of metastatic origin is a frequent pathology in patients with osteophilic tumor, despite adequate measures, the prognosis remains unresolved. Emphasis should be placed on raising awareness of different early diagnostic measures.},
 year = {2021}
}

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