Research Article
Epidemiological and Histopathological Profile of Prostate Cancer in Conakry
Diallo Thierno Mamadou Oury*,
Bah Mamadou Bissiriou,
Cissé Demba,
Agossou Ahouéfa Diodirine,
Bah Mamadou Diawo,
Diallo Alimou,
Diallo Thierno Oumar,
Keita Youssouf,
Kolié Aimé,
Diallo Abdoulaye Bobo,
Bah Oumar Raphiou
Issue:
Volume 11, Issue 4, December 2023
Pages:
122-126
Received:
Sep. 21, 2023
Accepted:
Oct. 30, 2023
Published:
Nov. 11, 2023
DOI:
10.11648/j.crj.20231104.11
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Abstract: Introduction: Prostate cancer is the most common male cancer. The aim of this work was to analyze the evolution of the epidemiological and histopathological profile of prostate cancer in the urology department at the Ignace Deen National Hospital in Conakry. Materials and methods: This was a descriptive retrospective study in 10 years, from January 1, 2011 to December 31, 2020. The data was collected from records available in the archives of the Ignace National Hospital Deen of Conakry. Results: 963 cases of prostate cancer were collected, representing 75% of urogenital cancers. We have observed a constant annual growth of cases, with an annual average of 96 cases. The mean age of the patients was 67 ± 13.56 years, with extremes of [47 - 102 years]. Farmers were the most affected with 36.3% of cases; 9.9% of patients (n=92) were smokers. Patients consulted more often with a delay of more than 12 months. Prostatic adenocarcinoma was the most found histological type with 99.8% of cases. More than half of the patients (62%) had a Gleason score of 3+3 (ISUP 1). Conclusion: Prostate cancer remains frequent representing the first urological cancer in Conakry. Prostatic adenocarcinoma is the main histological type. This study encountered difficulties related to the lack of a reliable data collection system.
Abstract: Introduction: Prostate cancer is the most common male cancer. The aim of this work was to analyze the evolution of the epidemiological and histopathological profile of prostate cancer in the urology department at the Ignace Deen National Hospital in Conakry. Materials and methods: This was a descriptive retrospective study in 10 years, from January...
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Research Article
Mesonephric-Like Adenocarcinoma of the Endometrium Mimicking Advanced Tubo-Ovarian Cancer - A Literature Review Based on a Special Case
Grit Gesine Ruth Hiller*,
Anne Kathrin Höhn,
Irene Krücken,
Anne Hagert-Winkler,
Mireille Martin,
Adrian Pilny,
Helmut Plett,
Christine Elisabeth Brambs,
Lars-Christian Horn
Issue:
Volume 11, Issue 4, December 2023
Pages:
127-135
Received:
Sep. 06, 2023
Accepted:
Sep. 28, 2023
Published:
Nov. 17, 2023
DOI:
10.11648/j.crj.20231104.12
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Abstract: Mesonephric-like adenocarcinoma of the endometrium (ML-AC) is a rare variant of endometrial adenocarcinoma with aggressive clinical behavior and unusual metastatic spread. Because of its rarity, the diagnosis may be challenging but needs to be accurate due to the mostly poor prognostic outcome of these tumors. To aid in the understanding and recognition of this entity we present the detailed histopathological, immunohistochemical and molecular analysis of a case of ML-AC clinically mimicking advanced ovarian cancer in a 55-year-old woman and put it in the context of literature research on ovarian and endometrial carcinomas. In the present case the patient revealed abdominal distension, ascites and a moderately elevated CA-125 level (504.8 U/ml) with widespread peritoneal carcinomatosis and an endometrial lesion confined to the endometrium with the presence of free-floating tumor cells within the tubal lumen, suggesting transtubal peritoneal spread of the endometrial primary. All tumor sites shared various architectural patterns on histology with negative staining for p16, WT-1 and estrogen receptor and positivity for TTF-1. Matched pair molecular analysis revealed an identic clonal KRAS-mutation (p.G12C) within the endometrial, peritoneal and lymph node involvement as well as in the recurrent tumor. There was retained mismatch repair protein staining and p53 wild type pattern without any additional mutational alterations, including POLE. A hepatic recurrence was diagnosed after 11 months. Literature study confirms our findings and the suggestion of a morphomolecular diagnostic approach additional to the fact that KRAS-mutation may represent a targetable alteration within a specialized therapeutic approach for this entity.
Abstract: Mesonephric-like adenocarcinoma of the endometrium (ML-AC) is a rare variant of endometrial adenocarcinoma with aggressive clinical behavior and unusual metastatic spread. Because of its rarity, the diagnosis may be challenging but needs to be accurate due to the mostly poor prognostic outcome of these tumors. To aid in the understanding and recogn...
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