Expression of HER2 in Gastric Carcinoma According to Tumor Location

Monoar Hossain; Miranur Rahman; Mohammad Sahajadul Alam; Monzurul Islam

doi:doi:10.11648/j.crj.20210902.14

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Expression of HER2 in Gastric Carcinoma According to Tumor Location

Monoar Hossain, Miranur Rahman, Mohammad Sahajadul Alam, Monzurul Islam

Published in Cancer Research Journal (Volume 9, Issue 2)

Received: 22 April 2021 Accepted: 31 May 2021 Published: 7 June 2021

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Abstract

Introduction: HER2/neu (c-erbB-2) is an oncogene that encodes a transmembrane glycoprotein with tyrosine kinase activity known as 185 kDa. This 185 kDa belongs to the epidermal growth factor receptor. Though HER-2 expression has been extensively found in advanced gastric cancer, few recent studies have evaluated the same in early gastric cancers. HER-2 overexpression is considered one of the poorest prognostic variables after nodal status in early gastric cancers too. Aim of the study: To find out the expression of HER2 in gastric carcinoma according to tumor location. Material & Methods: This cross-sectional study was conducted in the Department of Surgical Oncology of National Institute of Cancer, Research and Hospital, Mohakhali, Dhaka. The study period was from March 2014 to April 2015. A total of 80 patients were included in the study. After receiving the gastrectomy specimen, it was fixed in 10% formaldehyde. Statistical analysis was carried out using a computer-based software package for social science (SPSS 16.1). Ethical clearance was taken from the ethical committee of NICRH. Results: The highest patients were from the 61-70 years age group and the lowest were from 71-80 years. The mean age of the patients was 59.71 (±10.19) years. The female to male ratio in this study was 1: 2.48. The leading number of patients presented with abdominal pain where the vague abdominal discomfort was also included. They were 75%. This clinical condition was followed by vomiting which coined 58.75% of respondents. Out of 80 patients, 27 (33.75%) patients bore A +ve blood group whereas 23 (28.75%) patients had B+ve blood group. Most of the tumors were located in the distal (Noncardiac) part of the stomach (75%). Regarding staging 79 (98.75%) patients were in the advanced stage of the disease. Most of the tumors were located in the distal part of the stomach (11.67%). Conclusion: We reported a 12.5% of positive HER2 expression (IHC=3+ & 2+) in a series of 80 surgical specimens of gastric cancer patients. We also observed that positive HER2 expression varied depending on the histology and the primary tumor localization.

Published in	Cancer Research Journal (Volume 9, Issue 2)
DOI	10.11648/j.crj.20210902.14
Page(s)	106-110
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Expression, HER2/neu, Gastric Carcinoma, Tumor, Growth Factor

References

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[7]	Sakai K, Mori S, Kawamoto T, Taniguchi S, Kobori O, Morioka Y, Kuroki T, Kano K. Expression of epidermal growth factor receptors on normal human gastric epithelia and gastric carcinomas. Journal of the National Cancer Institute. 1986 Nov 1; 77 (5): 1047-52.
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[11]	Yano, T., Doi, T., Ohtsu, A., Boku, N., Hashizume, K., Nakanishi, M., & Ochiai, A. (2006). Comparison of HER2 gene amplification assessed by fluorescence in situ hybridization and HER2 protein expression assessed by immunohistochemistry in gastric cancer. Oncology reports, 15 (1), 65–71.
[12]	Bang, Y. J., Van Cutsem, E., Feyereislova, A., Chung, H. C., Shen, L., Sawaki, A., Lordick, F., Ohtsu, A., Omuro, Y., Satoh, T., Aprile, G., Kulikov, E., Hill, J., Lehle, M., Rüschoff, J., Kang, Y. K., & ToGA Trial Investigators (2010). Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. Lancet (London, England), 376 (9742), 687–697. https://doi.org/10.1016/S0140-6736(10)61121-X
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APA Style

Monoar Hossain, Miranur Rahman, Mohammad Sahajadul Alam, Monzurul Islam. (2021). Expression of HER2 in Gastric Carcinoma According to Tumor Location. Cancer Research Journal, 9(2), 106-110. https://doi.org/10.11648/j.crj.20210902.14

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ACS Style

Monoar Hossain; Miranur Rahman; Mohammad Sahajadul Alam; Monzurul Islam. Expression of HER2 in Gastric Carcinoma According to Tumor Location. Cancer Res. J. 2021, 9(2), 106-110. doi: 10.11648/j.crj.20210902.14

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AMA Style

Monoar Hossain, Miranur Rahman, Mohammad Sahajadul Alam, Monzurul Islam. Expression of HER2 in Gastric Carcinoma According to Tumor Location. Cancer Res J. 2021;9(2):106-110. doi: 10.11648/j.crj.20210902.14

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@article{10.11648/j.crj.20210902.14,
  author = {Monoar Hossain and Miranur Rahman and Mohammad Sahajadul Alam and Monzurul Islam},
  title = {Expression of HER2 in Gastric Carcinoma According to Tumor Location},
  journal = {Cancer Research Journal},
  volume = {9},
  number = {2},
  pages = {106-110},
  doi = {10.11648/j.crj.20210902.14},
  url = {https://doi.org/10.11648/j.crj.20210902.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20210902.14},
  abstract = {Introduction: HER2/neu (c-erbB-2) is an oncogene that encodes a transmembrane glycoprotein with tyrosine kinase activity known as 185 kDa. This 185 kDa belongs to the epidermal growth factor receptor. Though HER-2 expression has been extensively found in advanced gastric cancer, few recent studies have evaluated the same in early gastric cancers. HER-2 overexpression is considered one of the poorest prognostic variables after nodal status in early gastric cancers too. Aim of the study: To find out the expression of HER2 in gastric carcinoma according to tumor location. Material & Methods: This cross-sectional study was conducted in the Department of Surgical Oncology of National Institute of Cancer, Research and Hospital, Mohakhali, Dhaka. The study period was from March 2014 to April 2015. A total of 80 patients were included in the study. After receiving the gastrectomy specimen, it was fixed in 10% formaldehyde. Statistical analysis was carried out using a computer-based software package for social science (SPSS 16.1). Ethical clearance was taken from the ethical committee of NICRH. Results: The highest patients were from the 61-70 years age group and the lowest were from 71-80 years. The mean age of the patients was 59.71 (±10.19) years. The female to male ratio in this study was 1: 2.48. The leading number of patients presented with abdominal pain where the vague abdominal discomfort was also included. They were 75%. This clinical condition was followed by vomiting which coined 58.75% of respondents. Out of 80 patients, 27 (33.75%) patients bore A +ve blood group whereas 23 (28.75%) patients had B+ve blood group. Most of the tumors were located in the distal (Noncardiac) part of the stomach (75%). Regarding staging 79 (98.75%) patients were in the advanced stage of the disease. Most of the tumors were located in the distal part of the stomach (11.67%). Conclusion: We reported a 12.5% of positive HER2 expression (IHC=3+ & 2+) in a series of 80 surgical specimens of gastric cancer patients. We also observed that positive HER2 expression varied depending on the histology and the primary tumor localization.},
 year = {2021}
}

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TY - JOUR
T1 - Expression of HER2 in Gastric Carcinoma According to Tumor Location
AU - Monoar Hossain
AU - Miranur Rahman
AU - Mohammad Sahajadul Alam
AU - Monzurul Islam
Y1 - 2021/06/07
PY - 2021
N1 - https://doi.org/10.11648/j.crj.20210902.14
DO - 10.11648/j.crj.20210902.14
T2 - Cancer Research Journal
JF - Cancer Research Journal
JO - Cancer Research Journal
SP - 106
EP - 110
PB - Science Publishing Group
SN - 2330-8214
UR - https://doi.org/10.11648/j.crj.20210902.14
AB - Introduction: HER2/neu (c-erbB-2) is an oncogene that encodes a transmembrane glycoprotein with tyrosine kinase activity known as 185 kDa. This 185 kDa belongs to the epidermal growth factor receptor. Though HER-2 expression has been extensively found in advanced gastric cancer, few recent studies have evaluated the same in early gastric cancers. HER-2 overexpression is considered one of the poorest prognostic variables after nodal status in early gastric cancers too. Aim of the study: To find out the expression of HER2 in gastric carcinoma according to tumor location. Material & Methods: This cross-sectional study was conducted in the Department of Surgical Oncology of National Institute of Cancer, Research and Hospital, Mohakhali, Dhaka. The study period was from March 2014 to April 2015. A total of 80 patients were included in the study. After receiving the gastrectomy specimen, it was fixed in 10% formaldehyde. Statistical analysis was carried out using a computer-based software package for social science (SPSS 16.1). Ethical clearance was taken from the ethical committee of NICRH. Results: The highest patients were from the 61-70 years age group and the lowest were from 71-80 years. The mean age of the patients was 59.71 (±10.19) years. The female to male ratio in this study was 1: 2.48. The leading number of patients presented with abdominal pain where the vague abdominal discomfort was also included. They were 75%. This clinical condition was followed by vomiting which coined 58.75% of respondents. Out of 80 patients, 27 (33.75%) patients bore A +ve blood group whereas 23 (28.75%) patients had B+ve blood group. Most of the tumors were located in the distal (Noncardiac) part of the stomach (75%). Regarding staging 79 (98.75%) patients were in the advanced stage of the disease. Most of the tumors were located in the distal part of the stomach (11.67%). Conclusion: We reported a 12.5% of positive HER2 expression (IHC=3+ & 2+) in a series of 80 surgical specimens of gastric cancer patients. We also observed that positive HER2 expression varied depending on the histology and the primary tumor localization.
VL - 9
IS - 2
ER -

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Author Information

Monoar Hossain

Department of Surgery, Khulna Medical College, Khulna, Bangladesh
Miranur Rahman

National Institute of Cancer Research & Hospital (NICRH), Dhaka, Bangladesh
Mohammad Sahajadul Alam

Department of Surgical Oncology, National Institute of Cancer Research & Hospital (NICRH), Dhaka, Bangladesh
Monzurul Islam

Department of Surgical Oncology, National Institute of Cancer Research & Hospital (NICRH), Dhaka, Bangladesh

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APA Style

Monoar Hossain, Miranur Rahman, Mohammad Sahajadul Alam, Monzurul Islam. (2021). Expression of HER2 in Gastric Carcinoma According to Tumor Location. Cancer Research Journal, 9(2), 106-110. https://doi.org/10.11648/j.crj.20210902.14

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ACS Style

Monoar Hossain; Miranur Rahman; Mohammad Sahajadul Alam; Monzurul Islam. Expression of HER2 in Gastric Carcinoma According to Tumor Location. Cancer Res. J. 2021, 9(2), 106-110. doi: 10.11648/j.crj.20210902.14

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AMA Style

Monoar Hossain, Miranur Rahman, Mohammad Sahajadul Alam, Monzurul Islam. Expression of HER2 in Gastric Carcinoma According to Tumor Location. Cancer Res J. 2021;9(2):106-110. doi: 10.11648/j.crj.20210902.14

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@article{10.11648/j.crj.20210902.14,
  author = {Monoar Hossain and Miranur Rahman and Mohammad Sahajadul Alam and Monzurul Islam},
  title = {Expression of HER2 in Gastric Carcinoma According to Tumor Location},
  journal = {Cancer Research Journal},
  volume = {9},
  number = {2},
  pages = {106-110},
  doi = {10.11648/j.crj.20210902.14},
  url = {https://doi.org/10.11648/j.crj.20210902.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20210902.14},
  abstract = {Introduction: HER2/neu (c-erbB-2) is an oncogene that encodes a transmembrane glycoprotein with tyrosine kinase activity known as 185 kDa. This 185 kDa belongs to the epidermal growth factor receptor. Though HER-2 expression has been extensively found in advanced gastric cancer, few recent studies have evaluated the same in early gastric cancers. HER-2 overexpression is considered one of the poorest prognostic variables after nodal status in early gastric cancers too. Aim of the study: To find out the expression of HER2 in gastric carcinoma according to tumor location. Material & Methods: This cross-sectional study was conducted in the Department of Surgical Oncology of National Institute of Cancer, Research and Hospital, Mohakhali, Dhaka. The study period was from March 2014 to April 2015. A total of 80 patients were included in the study. After receiving the gastrectomy specimen, it was fixed in 10% formaldehyde. Statistical analysis was carried out using a computer-based software package for social science (SPSS 16.1). Ethical clearance was taken from the ethical committee of NICRH. Results: The highest patients were from the 61-70 years age group and the lowest were from 71-80 years. The mean age of the patients was 59.71 (±10.19) years. The female to male ratio in this study was 1: 2.48. The leading number of patients presented with abdominal pain where the vague abdominal discomfort was also included. They were 75%. This clinical condition was followed by vomiting which coined 58.75% of respondents. Out of 80 patients, 27 (33.75%) patients bore A +ve blood group whereas 23 (28.75%) patients had B+ve blood group. Most of the tumors were located in the distal (Noncardiac) part of the stomach (75%). Regarding staging 79 (98.75%) patients were in the advanced stage of the disease. Most of the tumors were located in the distal part of the stomach (11.67%). Conclusion: We reported a 12.5% of positive HER2 expression (IHC=3+ & 2+) in a series of 80 surgical specimens of gastric cancer patients. We also observed that positive HER2 expression varied depending on the histology and the primary tumor localization.},
 year = {2021}
}

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