Spectrum of HIV Associated Malignancies: A Retrospective Study of 42 Patients over a Period of 16 Years Attending a Tertiary Care Hospital

Rajendra Kumar Tanwar; Bharti Saxena; Manu Singh Tanwar; Abhirup Chatterjee; Harsh Goyal; Naveen Saxena; Raghuveer Singh; Madhu Saxena; Uma Shankar Shukla

doi:doi:10.11648/j.crj.20210903.11

Spectrum of HIV Associated Malignancies: A Retrospective Study of 42 Patients over a Period of 16 Years Attending a Tertiary Care Hospital

Rajendra Kumar Tanwar, Bharti Saxena, Manu Singh Tanwar, Abhirup Chatterjee, Harsh Goyal, Naveen Saxena, Raghuveer Singh, Madhu Saxena, Uma Shankar Shukla

Published in Cancer Research Journal (Volume 9, Issue 3)

Received: 15 June 2021 Accepted: 30 June 2021 Published: 7 July 2021

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Abstract

Introduction: The Human immunodeficiency virus (HIV) infection remains a serious public health concern in India and around the world at large. Malignancy is frequent among people living with HIV (PLWH) has become the leading cause of death. The incidence of malignancy among PLWH depends on various factors; virological control under combined antiretroviral therapy (cART), the exposure to oncogenic virus is of utmost importance, which can be prevented with the implementation of specific screening programs. Drug-drug interactions between cART and oncologic treatments can lead to serious adverse effects or to a reduction in the therapeutic effects requiring close monitoring. Methods: This is a single center retrospective study conducted on 42 seropositive patients attending a tertiary care oncology department from July 2005 to June 2021 to assess the demographic profile; laboratory investigations, clinico-pathological correlation, treatment outcome and survival follow up. Results: A total of 26410 patients were registered in the department during this period, out of which 42 (0.16%) were found to be HIV positive. These included head & neck -13; uterine cervix-7; lung -4; esophagus-4; NHL-4; recto sigmoid -3; breast-3; gall bladder; endometrium, choriocarcinoma (CCA) and acute myeloid leukemia (AML) one each. Conclusion; Seropositive patients often present in advanced stage of disease but have a good prognosis if treated appropriately with anti-retroviral therapy (ART). Very few studies have been published in India regarding the incidence of malignancy in HIV patients credited as one of the largest study published till date.

Published in	Cancer Research Journal (Volume 9, Issue 3)
DOI	10.11648/j.crj.20210903.11
Page(s)	131-139
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

HIV, NADC, ADC, Kaposi Sarcoma, NHL, Oral Squamous Cell Carcinoma, Immune Checkpoint Inhibitor

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APA Style

Rajendra Kumar Tanwar, Bharti Saxena, Manu Singh Tanwar, Abhirup Chatterjee, Harsh Goyal, et al. (2021). Spectrum of HIV Associated Malignancies: A Retrospective Study of 42 Patients over a Period of 16 Years Attending a Tertiary Care Hospital. Cancer Research Journal, 9(3), 131-139. https://doi.org/10.11648/j.crj.20210903.11

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ACS Style

Rajendra Kumar Tanwar; Bharti Saxena; Manu Singh Tanwar; Abhirup Chatterjee; Harsh Goyal, et al. Spectrum of HIV Associated Malignancies: A Retrospective Study of 42 Patients over a Period of 16 Years Attending a Tertiary Care Hospital. Cancer Res. J. 2021, 9(3), 131-139. doi: 10.11648/j.crj.20210903.11

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AMA Style

Rajendra Kumar Tanwar, Bharti Saxena, Manu Singh Tanwar, Abhirup Chatterjee, Harsh Goyal, et al. Spectrum of HIV Associated Malignancies: A Retrospective Study of 42 Patients over a Period of 16 Years Attending a Tertiary Care Hospital. Cancer Res J. 2021;9(3):131-139. doi: 10.11648/j.crj.20210903.11

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@article{10.11648/j.crj.20210903.11,
  author = {Rajendra Kumar Tanwar and Bharti Saxena and Manu Singh Tanwar and Abhirup Chatterjee and Harsh Goyal and Naveen Saxena and Raghuveer Singh and Madhu Saxena and Uma Shankar Shukla},
  title = {Spectrum of HIV Associated Malignancies: A Retrospective Study of 42 Patients over a Period of 16 Years Attending a Tertiary Care Hospital},
  journal = {Cancer Research Journal},
  volume = {9},
  number = {3},
  pages = {131-139},
  doi = {10.11648/j.crj.20210903.11},
  url = {https://doi.org/10.11648/j.crj.20210903.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20210903.11},
  abstract = {Introduction: The Human immunodeficiency virus (HIV) infection remains a serious public health concern in India and around the world at large. Malignancy is frequent among people living with HIV (PLWH) has become the leading cause of death. The incidence of malignancy among PLWH depends on various factors; virological control under combined antiretroviral therapy (cART), the exposure to oncogenic virus is of utmost importance, which can be prevented with the implementation of specific screening programs. Drug-drug interactions between cART and oncologic treatments can lead to serious adverse effects or to a reduction in the therapeutic effects requiring close monitoring. Methods: This is a single center retrospective study conducted on 42 seropositive patients attending a tertiary care oncology department from July 2005 to June 2021 to assess the demographic profile; laboratory investigations, clinico-pathological correlation, treatment outcome and survival follow up. Results: A total of 26410 patients were registered in the department during this period, out of which 42 (0.16%) were found to be HIV positive. These included head & neck -13; uterine cervix-7; lung -4; esophagus-4; NHL-4; recto sigmoid -3; breast-3; gall bladder; endometrium, choriocarcinoma (CCA) and acute myeloid leukemia (AML) one each. Conclusion; Seropositive patients often present in advanced stage of disease but have a good prognosis if treated appropriately with anti-retroviral therapy (ART). Very few studies have been published in India regarding the incidence of malignancy in HIV patients credited as one of the largest study published till date.},
 year = {2021}
}

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TY  - JOUR
T1  - Spectrum of HIV Associated Malignancies: A Retrospective Study of 42 Patients over a Period of 16 Years Attending a Tertiary Care Hospital
AU  - Rajendra Kumar Tanwar
AU  - Bharti Saxena
AU  - Manu Singh Tanwar
AU  - Abhirup Chatterjee
AU  - Harsh Goyal
AU  - Naveen Saxena
AU  - Raghuveer Singh
AU  - Madhu Saxena
AU  - Uma Shankar Shukla
Y1  - 2021/07/07
PY  - 2021
N1  - https://doi.org/10.11648/j.crj.20210903.11
DO  - 10.11648/j.crj.20210903.11
T2  - Cancer Research Journal
JF  - Cancer Research Journal
JO  - Cancer Research Journal
SP  - 131
EP  - 139
PB  - Science Publishing Group
SN  - 2330-8214
UR  - https://doi.org/10.11648/j.crj.20210903.11
AB  - Introduction: The Human immunodeficiency virus (HIV) infection remains a serious public health concern in India and around the world at large. Malignancy is frequent among people living with HIV (PLWH) has become the leading cause of death. The incidence of malignancy among PLWH depends on various factors; virological control under combined antiretroviral therapy (cART), the exposure to oncogenic virus is of utmost importance, which can be prevented with the implementation of specific screening programs. Drug-drug interactions between cART and oncologic treatments can lead to serious adverse effects or to a reduction in the therapeutic effects requiring close monitoring. Methods: This is a single center retrospective study conducted on 42 seropositive patients attending a tertiary care oncology department from July 2005 to June 2021 to assess the demographic profile; laboratory investigations, clinico-pathological correlation, treatment outcome and survival follow up. Results: A total of 26410 patients were registered in the department during this period, out of which 42 (0.16%) were found to be HIV positive. These included head & neck -13; uterine cervix-7; lung -4; esophagus-4; NHL-4; recto sigmoid -3; breast-3; gall bladder; endometrium, choriocarcinoma (CCA) and acute myeloid leukemia (AML) one each. Conclusion; Seropositive patients often present in advanced stage of disease but have a good prognosis if treated appropriately with anti-retroviral therapy (ART). Very few studies have been published in India regarding the incidence of malignancy in HIV patients credited as one of the largest study published till date.
VL  - 9
IS  - 3
ER  -

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Author Information

Rajendra Kumar Tanwar

Department of Radiation Oncology, Rajasthan University of Health Sciences, Jaipur, India
Bharti Saxena

Department of Obstetrics and Gynecology, Rajasthan University of Health Sciences, Jaipur, India
Manu Singh Tanwar

Department of Conservative Dentistry & Endodontics, Maharishi Markandeshwar University, Ambala, India
Abhirup Chatterjee

Department of General Dentistry, Rajasthan University of Health Sciences, Jaipur, India
Harsh Goyal

Department of Radiation Oncology, Rajasthan University of Health Sciences, Jaipur, India
Naveen Saxena

Department of Microbiology, Rajasthan University of Health Sciences, Jaipur, India
Raghuveer Singh

Department of Community Medicine, Rajasthan University of Health Sciences, Jaipur, India
Madhu Saxena

Department of Anesthesiology, Rajasthan University of Health Sciences, Jaipur, India
Uma Shankar Shukla

Department of Community Medicine, Rajasthan University of Health Sciences, Jaipur, India

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APA Style

Rajendra Kumar Tanwar, Bharti Saxena, Manu Singh Tanwar, Abhirup Chatterjee, Harsh Goyal, et al. (2021). Spectrum of HIV Associated Malignancies: A Retrospective Study of 42 Patients over a Period of 16 Years Attending a Tertiary Care Hospital. Cancer Research Journal, 9(3), 131-139. https://doi.org/10.11648/j.crj.20210903.11

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ACS Style

Rajendra Kumar Tanwar; Bharti Saxena; Manu Singh Tanwar; Abhirup Chatterjee; Harsh Goyal, et al. Spectrum of HIV Associated Malignancies: A Retrospective Study of 42 Patients over a Period of 16 Years Attending a Tertiary Care Hospital. Cancer Res. J. 2021, 9(3), 131-139. doi: 10.11648/j.crj.20210903.11

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AMA Style

Rajendra Kumar Tanwar, Bharti Saxena, Manu Singh Tanwar, Abhirup Chatterjee, Harsh Goyal, et al. Spectrum of HIV Associated Malignancies: A Retrospective Study of 42 Patients over a Period of 16 Years Attending a Tertiary Care Hospital. Cancer Res J. 2021;9(3):131-139. doi: 10.11648/j.crj.20210903.11

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@article{10.11648/j.crj.20210903.11,
  author = {Rajendra Kumar Tanwar and Bharti Saxena and Manu Singh Tanwar and Abhirup Chatterjee and Harsh Goyal and Naveen Saxena and Raghuveer Singh and Madhu Saxena and Uma Shankar Shukla},
  title = {Spectrum of HIV Associated Malignancies: A Retrospective Study of 42 Patients over a Period of 16 Years Attending a Tertiary Care Hospital},
  journal = {Cancer Research Journal},
  volume = {9},
  number = {3},
  pages = {131-139},
  doi = {10.11648/j.crj.20210903.11},
  url = {https://doi.org/10.11648/j.crj.20210903.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20210903.11},
  abstract = {Introduction: The Human immunodeficiency virus (HIV) infection remains a serious public health concern in India and around the world at large. Malignancy is frequent among people living with HIV (PLWH) has become the leading cause of death. The incidence of malignancy among PLWH depends on various factors; virological control under combined antiretroviral therapy (cART), the exposure to oncogenic virus is of utmost importance, which can be prevented with the implementation of specific screening programs. Drug-drug interactions between cART and oncologic treatments can lead to serious adverse effects or to a reduction in the therapeutic effects requiring close monitoring. Methods: This is a single center retrospective study conducted on 42 seropositive patients attending a tertiary care oncology department from July 2005 to June 2021 to assess the demographic profile; laboratory investigations, clinico-pathological correlation, treatment outcome and survival follow up. Results: A total of 26410 patients were registered in the department during this period, out of which 42 (0.16%) were found to be HIV positive. These included head & neck -13; uterine cervix-7; lung -4; esophagus-4; NHL-4; recto sigmoid -3; breast-3; gall bladder; endometrium, choriocarcinoma (CCA) and acute myeloid leukemia (AML) one each. Conclusion; Seropositive patients often present in advanced stage of disease but have a good prognosis if treated appropriately with anti-retroviral therapy (ART). Very few studies have been published in India regarding the incidence of malignancy in HIV patients credited as one of the largest study published till date.},
 year = {2021}
}

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TY  - JOUR
T1  - Spectrum of HIV Associated Malignancies: A Retrospective Study of 42 Patients over a Period of 16 Years Attending a Tertiary Care Hospital
AU  - Rajendra Kumar Tanwar
AU  - Bharti Saxena
AU  - Manu Singh Tanwar
AU  - Abhirup Chatterjee
AU  - Harsh Goyal
AU  - Naveen Saxena
AU  - Raghuveer Singh
AU  - Madhu Saxena
AU  - Uma Shankar Shukla
Y1  - 2021/07/07
PY  - 2021
N1  - https://doi.org/10.11648/j.crj.20210903.11
DO  - 10.11648/j.crj.20210903.11
T2  - Cancer Research Journal
JF  - Cancer Research Journal
JO  - Cancer Research Journal
SP  - 131
EP  - 139
PB  - Science Publishing Group
SN  - 2330-8214
UR  - https://doi.org/10.11648/j.crj.20210903.11
AB  - Introduction: The Human immunodeficiency virus (HIV) infection remains a serious public health concern in India and around the world at large. Malignancy is frequent among people living with HIV (PLWH) has become the leading cause of death. The incidence of malignancy among PLWH depends on various factors; virological control under combined antiretroviral therapy (cART), the exposure to oncogenic virus is of utmost importance, which can be prevented with the implementation of specific screening programs. Drug-drug interactions between cART and oncologic treatments can lead to serious adverse effects or to a reduction in the therapeutic effects requiring close monitoring. Methods: This is a single center retrospective study conducted on 42 seropositive patients attending a tertiary care oncology department from July 2005 to June 2021 to assess the demographic profile; laboratory investigations, clinico-pathological correlation, treatment outcome and survival follow up. Results: A total of 26410 patients were registered in the department during this period, out of which 42 (0.16%) were found to be HIV positive. These included head & neck -13; uterine cervix-7; lung -4; esophagus-4; NHL-4; recto sigmoid -3; breast-3; gall bladder; endometrium, choriocarcinoma (CCA) and acute myeloid leukemia (AML) one each. Conclusion; Seropositive patients often present in advanced stage of disease but have a good prognosis if treated appropriately with anti-retroviral therapy (ART). Very few studies have been published in India regarding the incidence of malignancy in HIV patients credited as one of the largest study published till date.
VL  - 9
IS  - 3
ER  -

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