Prognostic Significance of Platelet-to-Lymphocyte Ratio in Gliomas: A Meta-analysis

Huayue Cong; Aixia Sui; Liuyi Yang; Huiling Song; Jing Zhao; Yong Liu; Mingming Zhang; Weiliang He

doi:doi:10.11648/j.crj.20210903.12

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Prognostic Significance of Platelet-to-Lymphocyte Ratio in Gliomas: A Meta-analysis

Huayue Cong, Aixia Sui, Liuyi Yang, Huiling Song, Jing Zhao, Yong Liu, Mingming Zhang, Weiliang He

Published in Cancer Research Journal (Volume 9, Issue 3)

Received: 20 June 2021 Accepted: 30 June 2021 Published: 7 July 2021

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Abstract

Background and objective: Inflammatory factors are associated with tumour initiation, progression, invasion, and metastasis. It is a potential prognostic factor for multiple solid tumours. Such as cholangiocarcinoma, bladder cancer, nasopharyngeal carcinoma and so on. However, there is no clear evidence that elevation of the systemic inflammatory marker, platelet-to-lymphocyte ratio (PLR), has this type of predictive value in patients with glioma. This meta-analysis aimed to explored the prognostic significance of the preoperative inflammatory marker PLR in patients with glioma. Methods: Systematic retrieval of articles published between the time of their conception and September 2020 in PubMed, EMBASE, and Cochrane library databases, A meta-analysis was performed via Review Manager 5.3, using the hazard ratios (HRs) and 95% confidence intervals (95% CIs) for overall survival (OS) to assess the predictive significance of PLR in patients with glioma. Result: We selected nine studies and showed that in patients with glioma, increased PLR was correlated with poor OS (HR = 1.37, 95% CI: 1.09–1.71, P = 0.007, I² = 55%). By analysing the I², we estimated moderate heterogeneity in several of the published articles that were incorporated. Conclusion: Our meta-analysis provides evidence that increased PLR is correlated with poor OS in patients with glioma cancer.

Published in	Cancer Research Journal (Volume 9, Issue 3)
DOI	10.11648/j.crj.20210903.12
Page(s)	140-147
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Glioma, Platelet to Lymphocyte Ratio, Meta-analysis, Overall Survival

References

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APA Style

Huayue Cong, Aixia Sui, Liuyi Yang, Huiling Song, Jing Zhao, et al. (2021). Prognostic Significance of Platelet-to-Lymphocyte Ratio in Gliomas: A Meta-analysis. Cancer Research Journal, 9(3), 140-147. https://doi.org/10.11648/j.crj.20210903.12

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ACS Style

Huayue Cong; Aixia Sui; Liuyi Yang; Huiling Song; Jing Zhao, et al. Prognostic Significance of Platelet-to-Lymphocyte Ratio in Gliomas: A Meta-analysis. Cancer Res. J. 2021, 9(3), 140-147. doi: 10.11648/j.crj.20210903.12

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AMA Style

Huayue Cong, Aixia Sui, Liuyi Yang, Huiling Song, Jing Zhao, et al. Prognostic Significance of Platelet-to-Lymphocyte Ratio in Gliomas: A Meta-analysis. Cancer Res J. 2021;9(3):140-147. doi: 10.11648/j.crj.20210903.12

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@article{10.11648/j.crj.20210903.12,
  author = {Huayue Cong and Aixia Sui and Liuyi Yang and Huiling Song and Jing Zhao and Yong Liu and Mingming Zhang and Weiliang He},
  title = {Prognostic Significance of Platelet-to-Lymphocyte Ratio in Gliomas: A Meta-analysis},
  journal = {Cancer Research Journal},
  volume = {9},
  number = {3},
  pages = {140-147},
  doi = {10.11648/j.crj.20210903.12},
  url = {https://doi.org/10.11648/j.crj.20210903.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20210903.12},
  abstract = {Background and objective: Inflammatory factors are associated with tumour initiation, progression, invasion, and metastasis. It is a potential prognostic factor for multiple solid tumours. Such as cholangiocarcinoma, bladder cancer, nasopharyngeal carcinoma and so on. However, there is no clear evidence that elevation of the systemic inflammatory marker, platelet-to-lymphocyte ratio (PLR), has this type of predictive value in patients with glioma. This meta-analysis aimed to explored the prognostic significance of the preoperative inflammatory marker PLR in patients with glioma. Methods: Systematic retrieval of articles published between the time of their conception and September 2020 in PubMed, EMBASE, and Cochrane library databases, A meta-analysis was performed via Review Manager 5.3, using the hazard ratios (HRs) and 95% confidence intervals (95% CIs) for overall survival (OS) to assess the predictive significance of PLR in patients with glioma. Result: We selected nine studies and showed that in patients with glioma, increased PLR was correlated with poor OS (HR = 1.37, 95% CI: 1.09–1.71, P = 0.007, I2 = 55%). By analysing the I2, we estimated moderate heterogeneity in several of the published articles that were incorporated. Conclusion: Our meta-analysis provides evidence that increased PLR is correlated with poor OS in patients with glioma cancer.},
 year = {2021}
}

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TY  - JOUR
T1  - Prognostic Significance of Platelet-to-Lymphocyte Ratio in Gliomas: A Meta-analysis
AU  - Huayue Cong
AU  - Aixia Sui
AU  - Liuyi Yang
AU  - Huiling Song
AU  - Jing Zhao
AU  - Yong Liu
AU  - Mingming Zhang
AU  - Weiliang He
Y1  - 2021/07/07
PY  - 2021
N1  - https://doi.org/10.11648/j.crj.20210903.12
DO  - 10.11648/j.crj.20210903.12
T2  - Cancer Research Journal
JF  - Cancer Research Journal
JO  - Cancer Research Journal
SP  - 140
EP  - 147
PB  - Science Publishing Group
SN  - 2330-8214
UR  - https://doi.org/10.11648/j.crj.20210903.12
AB  - Background and objective: Inflammatory factors are associated with tumour initiation, progression, invasion, and metastasis. It is a potential prognostic factor for multiple solid tumours. Such as cholangiocarcinoma, bladder cancer, nasopharyngeal carcinoma and so on. However, there is no clear evidence that elevation of the systemic inflammatory marker, platelet-to-lymphocyte ratio (PLR), has this type of predictive value in patients with glioma. This meta-analysis aimed to explored the prognostic significance of the preoperative inflammatory marker PLR in patients with glioma. Methods: Systematic retrieval of articles published between the time of their conception and September 2020 in PubMed, EMBASE, and Cochrane library databases, A meta-analysis was performed via Review Manager 5.3, using the hazard ratios (HRs) and 95% confidence intervals (95% CIs) for overall survival (OS) to assess the predictive significance of PLR in patients with glioma. Result: We selected nine studies and showed that in patients with glioma, increased PLR was correlated with poor OS (HR = 1.37, 95% CI: 1.09–1.71, P = 0.007, I2 = 55%). By analysing the I2, we estimated moderate heterogeneity in several of the published articles that were incorporated. Conclusion: Our meta-analysis provides evidence that increased PLR is correlated with poor OS in patients with glioma cancer.
VL  - 9
IS  - 3
ER  -

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Author Information

Huayue Cong

Hebei General Hospital, Shijiazhuang, China
Aixia Sui

Hebei General Hospital, Shijiazhuang, China
Liuyi Yang

Hebei General Hospital, Shijiazhuang, China
Huiling Song

Hebei General Hospital, Shijiazhuang, China
Jing Zhao

Hebei General Hospital, Shijiazhuang, China
Yong Liu

Department of Oncology, Baoding First Central Hospital, Baoding, China
Mingming Zhang

Hebei General Hospital, Shijiazhuang, China
Weiliang He

Hebei General Hospital, Shijiazhuang, China

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APA Style

Huayue Cong, Aixia Sui, Liuyi Yang, Huiling Song, Jing Zhao, et al. (2021). Prognostic Significance of Platelet-to-Lymphocyte Ratio in Gliomas: A Meta-analysis. Cancer Research Journal, 9(3), 140-147. https://doi.org/10.11648/j.crj.20210903.12

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ACS Style

Huayue Cong; Aixia Sui; Liuyi Yang; Huiling Song; Jing Zhao, et al. Prognostic Significance of Platelet-to-Lymphocyte Ratio in Gliomas: A Meta-analysis. Cancer Res. J. 2021, 9(3), 140-147. doi: 10.11648/j.crj.20210903.12

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AMA Style

Huayue Cong, Aixia Sui, Liuyi Yang, Huiling Song, Jing Zhao, et al. Prognostic Significance of Platelet-to-Lymphocyte Ratio in Gliomas: A Meta-analysis. Cancer Res J. 2021;9(3):140-147. doi: 10.11648/j.crj.20210903.12

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@article{10.11648/j.crj.20210903.12,
  author = {Huayue Cong and Aixia Sui and Liuyi Yang and Huiling Song and Jing Zhao and Yong Liu and Mingming Zhang and Weiliang He},
  title = {Prognostic Significance of Platelet-to-Lymphocyte Ratio in Gliomas: A Meta-analysis},
  journal = {Cancer Research Journal},
  volume = {9},
  number = {3},
  pages = {140-147},
  doi = {10.11648/j.crj.20210903.12},
  url = {https://doi.org/10.11648/j.crj.20210903.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20210903.12},
  abstract = {Background and objective: Inflammatory factors are associated with tumour initiation, progression, invasion, and metastasis. It is a potential prognostic factor for multiple solid tumours. Such as cholangiocarcinoma, bladder cancer, nasopharyngeal carcinoma and so on. However, there is no clear evidence that elevation of the systemic inflammatory marker, platelet-to-lymphocyte ratio (PLR), has this type of predictive value in patients with glioma. This meta-analysis aimed to explored the prognostic significance of the preoperative inflammatory marker PLR in patients with glioma. Methods: Systematic retrieval of articles published between the time of their conception and September 2020 in PubMed, EMBASE, and Cochrane library databases, A meta-analysis was performed via Review Manager 5.3, using the hazard ratios (HRs) and 95% confidence intervals (95% CIs) for overall survival (OS) to assess the predictive significance of PLR in patients with glioma. Result: We selected nine studies and showed that in patients with glioma, increased PLR was correlated with poor OS (HR = 1.37, 95% CI: 1.09–1.71, P = 0.007, I2 = 55%). By analysing the I2, we estimated moderate heterogeneity in several of the published articles that were incorporated. Conclusion: Our meta-analysis provides evidence that increased PLR is correlated with poor OS in patients with glioma cancer.},
 year = {2021}
}

Copy | Download

TY  - JOUR
T1  - Prognostic Significance of Platelet-to-Lymphocyte Ratio in Gliomas: A Meta-analysis
AU  - Huayue Cong
AU  - Aixia Sui
AU  - Liuyi Yang
AU  - Huiling Song
AU  - Jing Zhao
AU  - Yong Liu
AU  - Mingming Zhang
AU  - Weiliang He
Y1  - 2021/07/07
PY  - 2021
N1  - https://doi.org/10.11648/j.crj.20210903.12
DO  - 10.11648/j.crj.20210903.12
T2  - Cancer Research Journal
JF  - Cancer Research Journal
JO  - Cancer Research Journal
SP  - 140
EP  - 147
PB  - Science Publishing Group
SN  - 2330-8214
UR  - https://doi.org/10.11648/j.crj.20210903.12
AB  - Background and objective: Inflammatory factors are associated with tumour initiation, progression, invasion, and metastasis. It is a potential prognostic factor for multiple solid tumours. Such as cholangiocarcinoma, bladder cancer, nasopharyngeal carcinoma and so on. However, there is no clear evidence that elevation of the systemic inflammatory marker, platelet-to-lymphocyte ratio (PLR), has this type of predictive value in patients with glioma. This meta-analysis aimed to explored the prognostic significance of the preoperative inflammatory marker PLR in patients with glioma. Methods: Systematic retrieval of articles published between the time of their conception and September 2020 in PubMed, EMBASE, and Cochrane library databases, A meta-analysis was performed via Review Manager 5.3, using the hazard ratios (HRs) and 95% confidence intervals (95% CIs) for overall survival (OS) to assess the predictive significance of PLR in patients with glioma. Result: We selected nine studies and showed that in patients with glioma, increased PLR was correlated with poor OS (HR = 1.37, 95% CI: 1.09–1.71, P = 0.007, I2 = 55%). By analysing the I2, we estimated moderate heterogeneity in several of the published articles that were incorporated. Conclusion: Our meta-analysis provides evidence that increased PLR is correlated with poor OS in patients with glioma cancer.
VL  - 9
IS  - 3
ER  -

Copy | Download