Pregnant and Postpartum Women with Atypical Glandular Cells: Follow-up and Evaluation for High-Risk HPV
Issue:
Volume 1, Issue 4, November 2013
Pages:
31-36
Received:
15 October 2013
Published:
10 November 2013
Abstract: Objectives: The study was an attempt: to find out the prevalence of atypical glandular cells of undetermined significance (AGC) in cervicovaginal smears of pregnant and postpartum women in Duhok-Iraq; follow up these women to investigate the underlying pathology and to test for high-risk HPV (HR-HPV). Methods: From May 2005 to June 2013, all Pap smears of pregnant and postpartum women were analyzed and women with AGC cytology were enrolled in the study. One hundred and fifty two women, for whom follow up was possible, were subjected to colposcopic directed cytology and/or histology for at least 48 months from the initial reading. Their results were comprehensively evaluated, and HR-HPV DNA testing was performed by conventional PCR in 56 cases. Results: Overall, AGC cytology formed 6.7% of all pregnant and postpartum women’s Pap smears and 29.6% were at risk for neoplastic epithelial lesions (AGC and premalignant lesions). The diagnosis of ≥ low squamous intraepithelial lesion (LSIL) was observed in 14.5% of cases among whom significantly high frequency of HR-HPV DNA was noted compared with those having persistent AGC or negative atypia (NILM). Conclusions: Identical to non-pregnant women, pregnant and postpartum women with AGC cytology are at risk of harboring premalignant and malignant (squamous or glandular) lesions, and testing of AGC cytologic specimens for HR-HPV might help predict neoplastic cases but not to distinguish malignant from premalignant lesions.
Abstract: Objectives: The study was an attempt: to find out the prevalence of atypical glandular cells of undetermined significance (AGC) in cervicovaginal smears of pregnant and postpartum women in Duhok-Iraq; follow up these women to investigate the underlying pathology and to test for high-risk HPV (HR-HPV). Methods: From May 2005 to June 2013, all Pap sm...
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Cancer of the Uterine Cervix at the University of Calabar Teaching Hospital, Calabar Nigeria
Boniface Uji Ago,
Thomas Udagbor Agan,
Etim Inyang Ekanem
Issue:
Volume 1, Issue 4, November 2013
Pages:
37-40
Received:
30 November 2013
Published:
10 January 2014
Abstract: Background: This study was carried out to highlight the prevalence of cancer of the uterine cervix and shortcoming in the management of cervical cancer in our hospital. There is the need to improve on our personnel training and equipment acquisition. Method: This was a retrospective study. Case folders of forty-seven patients who were diagnosed with cancer of the cervix were retrieved and reviewed. Information on age, parity, clinical presentation, stages of the disease and management as well as management problems were analyzed. Results: There were 1450 admissions into the gynaecology ward during the study. Forty patients had histologically confirmed cancer of the cervix. This gave cervical cancer a prevalence of 2.76% of gynaecology ward admissions in this center. 82.5% presented with late stage disease where little or nothing could be done for them. Conclusion: Cancer of the uterine cervix is still a problem in our setting where uptake of screening methods and the availability of cytopathologists are still dismally low.
Abstract: Background: This study was carried out to highlight the prevalence of cancer of the uterine cervix and shortcoming in the management of cervical cancer in our hospital. There is the need to improve on our personnel training and equipment acquisition. Method: This was a retrospective study. Case folders of forty-seven patients who were diagnosed wit...
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