Cancer Research Journal

Volume 3, Issue 3, May 2015

  • Lymphocytopenia and Cytotoxic Therapy in Patients with Advanced Ovarian Cancer

    Alexei N. Shoutko, Ludmila E. Yurkova, Kseniya S. Borodulya, Ludmila P. Ekimova

    Issue: Volume 3, Issue 3, May 2015
    Pages: 47-51
    Received: Apr. 13, 2015
    Accepted: Apr. 25, 2015
    Published: May 12, 2015
    Abstract: The relationship between 5-year survival and the mean number of circulating lymphocytes during 1 month after beginning a combined therapy was investigated in 175 patients with advanced epithelial ovarian cancer to understand why myelosuppression caused by a cytotoxic treatment is almost inseparable from its benefit. Patients received a combined the... Show More
  • Cell Migration Induced by Native Type IV Collagen Requires PI3K/Akt2 and EGFR Activity in MDA-MB-231 Breast Cancer Cells

    Emmanuel Reyes-Uribe, Octavio Galindo-Hernandez, Pedro Cortes-Reynosa, Eduardo Perez Salazar

    Issue: Volume 3, Issue 3, May 2015
    Pages: 52-62
    Received: May 06, 2015
    Accepted: May 26, 2015
    Published: Jun. 16, 2015
    Abstract: Basement membrane (BM) is a specialized extracellular matrix (ECM) that separates epithelial cells from surrounding stroma and regulates various biological processes including morphology, growth, differentiation, adhesion and motility. Type IV collagen is the major component of BM, provides structural framework of all BMs and interacts with cell su... Show More