Reliability of Visual Inspection After Acetic Acid Staining in Screening for Cervical Pre-malignant Lesion Among Female Subjects in a Rural Tertiary Hospital in Nigeria
Gabriel Olusegun Emmanuel,
Ajetunmobi Oluwaserimi Adewumi,
Akomolafe Akinwumi Oluwole,
Bushari Olusegun Adesola,
Adeniyi Adebayo Augustine,
Dada Samuel Ayokunle
Issue:
Volume 4, Issue 1, January 2016
Pages:
1-8
Received:
29 November 2015
Accepted:
21 December 2015
Published:
11 January 2016
Abstract: This study was carried out in order to assess the sensitivity and specificity of visual inspection after acetic acid staining (VIA) using Papanicolaou smear as the gold standard screening method for cervical premalignant lesion. Two hundred and twenty (220) consecutive and consenting women ages 20 – 70years, attending Federal Medical Centre, Ido-Ekiti, Ekiti State, were recruited. Relevant data were collected using interviewer-administered semi-structured questionnaires. In conclusion, the prevalence of pre-malignant lesion of cervical cancer is high in this study. It is therefore recommended that awareness of cervical cancer and its screening should be improved through health education campaigns. VIA can serve as an alternative to Papanicolaou smear in resource-limited countries, since it has high level of specificity and sensitivity as Papanicolaou smear.
Abstract: This study was carried out in order to assess the sensitivity and specificity of visual inspection after acetic acid staining (VIA) using Papanicolaou smear as the gold standard screening method for cervical premalignant lesion. Two hundred and twenty (220) consecutive and consenting women ages 20 – 70years, attending Federal Medical Centre, Ido-Ek...
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Dynamics of Magnetic Nanoparticles in Newly Formed Microvascular Networks Surrounding Solid Tumours: A Parallel Programming Approach
Issue:
Volume 4, Issue 1, January 2016
Pages:
9-23
Received:
14 December 2015
Accepted:
31 December 2015
Published:
21 January 2016
Abstract: In this paper we extend a previous 2D parallel implementation of a continuous-discrete model of tumour-induced angiogenesis. In particular, we examine the transport and capture of magnetic nanoparticles through a newly formed vascular network of blood vessels. We demonstrate how our models can be used to describe the dynamics of magnetic nanoparticles in a microvasculature and observe that the orientation of the blood vessels with respect to the magnetic force crucially affects particle capture rates leading to heterogeneous particle distributions. In addition, efficiency of magnetic particle capture depends on the ratio between the magnetic velocity and blood vessel aspect ratio. Such simulations allow a more detailed understanding of the use of magnetic nanoparticles as a mechanism for targeted anti-cancer drug delivery.
Abstract: In this paper we extend a previous 2D parallel implementation of a continuous-discrete model of tumour-induced angiogenesis. In particular, we examine the transport and capture of magnetic nanoparticles through a newly formed vascular network of blood vessels. We demonstrate how our models can be used to describe the dynamics of magnetic nanopartic...
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Profile of Polycythemia Vera in Campus Teaching Hospital of Lome - Togo
Padaro Essohana,
Kueviakoe Irenee Messanh Delagnon,
Layibo Yao,
Kolou Malewe,
Agbetiafa Kossi,
Stephane Giraudier,
Segbena Akuete Yvon
Issue:
Volume 4, Issue 1, January 2016
Pages:
24-27
Received:
29 January 2016
Accepted:
8 February 2016
Published:
29 February 2016
Abstract: Objective: To describe the clinical, epidemiological and biological profile of polycythemia vera. Patients and methods: This is a descriptive study done from May to October 2014 witch included 13 patient who had been treated since 2007 at Campus Teaching Hospital of Lomé for polycythemia vera. The research of JAK2 V617Fmutation by PCR was been done inmolecular biologylaboratory of the Henri Mondor Hospital at Creteil in France. Results: The annual prevalence of polycythemia vera is about 2.16 new cases. The average age of patients was 46, 7 years with ranges from 31 to 65 years. There were 9 men and 4 women. The most frequent factor of finding was the fortuitous ones (23%). Most clinical signs represented were headache (69.2%), skin érythroses (53.8%) and paresthesia (30.8%). The average value of hemoglobin, hematocrit, the number of white blood cells and platelets in our patients with polycythemia who had positive JAK2V617F was respectively: 198g/L ± 44; 62.7 ± 4.4%; 9.8 G/L ± 4.3, 630.4G /l ± 367.4. Those Who didn’t had JAK2mutation, had respectively: 179g/L ± 13.3; 59,0% ± 13.3; 7.5G/L ± 4.2 GB and 441.0G /L ± 564.7. Conclusion: The JAK2V617F mutation had an interestin polycythemia vera value in diagnosis and can be systematic even in Sub-Saharan African.
Abstract: Objective: To describe the clinical, epidemiological and biological profile of polycythemia vera. Patients and methods: This is a descriptive study done from May to October 2014 witch included 13 patient who had been treated since 2007 at Campus Teaching Hospital of Lomé for polycythemia vera. The research of JAK2 V617Fmutation by PCR was been done...
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