Cancer Research Journal

Volume 4, Issue 2, March 2016

  • Synergistic Anticancer Potential of Water Garlic Extract and Copper in a Human Hepatocarcinoma Cell Line

    Angelo De Martino, Piera Torricelli, Hanan Mahmoud Abu-Zeid, Anna Shevchenko, Alberto Siciliano, Simone Beninati

    Issue: Volume 4, Issue 2, March 2016
    Pages: 28-31
    Received: 2 February 2016
    Accepted: 18 February 2016
    Published: 1 March 2016
    Abstract: Garlic extract in water, supplemented with copper, exerts an enhanced anti-proliferative and a caspase-independent apoptotic activity in a human hepatocarcinoma HepG2 cancer cell line. Furthermore, a DNA double strand break downstream, likely responsible for the observed cell death in HepG2 cell, was evidenced by an early over expression of p53 and... Show More
  • The Benefit of Locoregional Surgical Intervention in Metastatic Breast Cancer at Initial Presentation

    Niveen A. Abo-Touk, Amir A. Fikry, El Yamani Fouda

    Issue: Volume 4, Issue 2, March 2016
    Pages: 32-36
    Received: 19 February 2016
    Accepted: 28 February 2016
    Published: 12 March 2016
    Abstract: This study aims to determine the value of locoregional surgery compared with no surgery on the outcome of women with metastatic breast cancer at initial presentation. For that, fifty seven patients initially presented with stage IV breast cancer were prospectively randomized to undergo mastectomy in group I (27 patients) or no surgery in group II (... Show More
  • Organ Culture Model of Liver for the Study of Cancer Treatment for Hepatocellular Carcinoma

    Torricelli Piera, Antonelli Francesco, Ferorelli Pasquale, De Martino Angelo, Shevchenko Anna, Siciliano Alberto, Beninati Simone

    Issue: Volume 4, Issue 2, March 2016
    Pages: 37-42
    Received: 22 February 2016
    Accepted: 1 March 2016
    Published: 16 March 2016
    Abstract: The liver, the largest organ of the human body, is a multifunctional organ with various metabolic activities that plays a fundamental role in maintaining the body and in sustaining life. Although the liver has great regenerative capacity and recovery, the damage caused by chronic diseases such as cancer or viral infections can lead to permanent los... Show More