Clinicopathological Properties of Non-Hodgkin Lymphomas in the South-West of Turkey
Erdal Kurtoğlu,
Mustafa Yıldırım,
Hülya Karakılınç,
Mustafa Yıldız,
Sevil Göktaş,
Dinç Süren,
Vildan Kaya
Issue:
Volume 1, Issue 2, July 2013
Pages:
15-19
Received:
27 June 2013
Published:
10 August 2013
Abstract: Objective: Non-Hodgkin Lymphomas, which have numerous histological subgroups, entail various biological behaviour, clinical properties and epidemiological differences. Incidence of histological subtypes can vary according to geographical locations. In this article, we will discuss clinicopathological properties of Non-Hodgkin Lymphoma patients in Antalya, which is located in the south-west of Turkey. Material and Method: This study used the data from 1994 to 2010 on the patients from the data bank of Turkish Ministry of Health, Antalya Provincial Health Directorate, Cancer Registration Center. Results: The study covered a total of 1521 patients, including 899 (59.1%) male and 622 (40.9%) female patients. One-hundred thirty (8.6%) of the patients were under the age of 20, 911 (60%) were aged between 20-65, and 477 (31.4%) were above the age of 65. Cellular origins of Non-Hodgkin Lymphomas were evaluated in 1518 patients. B-cell originated Non-Hodgkin Lymphoma was identified as the most common with 86.4% (Table 1). We also revealed that T-cell originated Non-Hodgkin Lymphomas were more common under the age of 20. Conclusions: Clinicopathologic properties of Non-Hodgkin Lymphomas vary across countries as well as across regions in a country. We believe that such differences should be taken into account in the diagnosis and treatment of these patients.
Abstract: Objective: Non-Hodgkin Lymphomas, which have numerous histological subgroups, entail various biological behaviour, clinical properties and epidemiological differences. Incidence of histological subtypes can vary according to geographical locations. In this article, we will discuss clinicopathological properties of Non-Hodgkin Lymphoma patients in A...
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Prognostic and Predictive Role of HER2 Expression in Metastatic Gastric Cancer in Turkish Patients
Mustafa Yıldırım,
Arsenal Sezgin,
Utku Dönem Dilli,
Dinc Süren,
Mustafa Yıldız,
Vildan Kaya,
Cem Sezer,
Nurullah Bülbüller
Issue:
Volume 1, Issue 2, July 2013
Pages:
20-25
Received:
20 June 2013
Published:
10 August 2013
Abstract: Background: In this study, we investigate the role of HER2 expression in prediction of the response to treatment combination including dosetaxel, cisplatin and 5-FU which is used in metastatic gastric cancer in Turkish patients. Methods: Patients who were histopathologically diagnosed with metastatic gastric cancer at the Antalya Training and Research Hospital, Clinic of Medical Oncology from 2008 to 2010 were included in this study. Results: IHC assessment identified 4 patients (25%) 0 / negative, 5 patients (31.3%) 1+ / negative, 4 patients (25%) 2 + / suspected, and 3 patients (18.8%) 3 + / positive. The relationship between HER2 expression and the response using chi-square test was not statistically significant. Conclusions: We believe that identification of patients who will respond to chemoterapy combination is important to prevent complications. The important shortcomings in our study include covering a small number of patients and the use of FISH method. Therefore, we believe that further studies using FISH method with more patients are required to investigate the role of HER2 expression in predicting the response to DCF chemotherapy combination.
Abstract: Background: In this study, we investigate the role of HER2 expression in prediction of the response to treatment combination including dosetaxel, cisplatin and 5-FU which is used in metastatic gastric cancer in Turkish patients. Methods: Patients who were histopathologically diagnosed with metastatic gastric cancer at the Antalya Training and Resea...
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