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Identification of Three Candidate Genes and Their Correlation with Drug Sensitivity in Acute Myeloid Leukemia
Fenling Zhou,
Yuli Cao,
Daxia Cai,
Jiajian Liang,
Cuilan Deng,
Gexiu Liu,
Dongmei He
Issue:
Volume 9, Issue 4, December 2021
Pages:
176-190
Received:
19 November 2021
Accepted:
10 December 2021
Published:
24 December 2021
Abstract: Background: Acute myeloid leukemia (AML) is a common hematopoietic tumor with extremely high morbidity and mortality. This study was designed to explore candidate genes that were related to the poor prognosis of AML patients and analyze their relationship with drug sensitivity. Methods: Microarray databases were performed to screen the differentially expressed genes (DEGs). DAVID 6.8 was used for further functional enrichment analysis. The protein-protein interaction (PPI) network was constructed through STRING website and Cytoscape tool. Then, we analyzed and explored the mRNA transcription level, prognosis correlation, and drug sensitivity of the candidate genes in AML via multiple acknowledged databases including the GEPIA, BloodSpot, EMBL-EBI, UALCAN, LinkedOmics, and GSCALite databases. Results: A total of 181 up-regulated DEGs were screened. Three candidate genes (MAP2K3, LST1, and CYTH4) related to poor outcomes of AML patients were identified. Meanwhile, the high expression levels of the three genes were verified in AML patients and AML cell lines, the expression differences of three genes at AML different subtypes were demonstrated. Drug sensitivity analysis displayed the expression levels of MAP2K3, LST1, and CYTH4 were negatively related to drug resistance, indicating that the three genes were sensitive to certain small-molecule drugs (including targeted drugs and non-targeted drugs). Conclusion: In summary, MAP2K3, LST1, and CYTH4 may be potential prognostic indicators for AML, and may be associated with the sensitivity of certain small molecule drugs.
Abstract: Background: Acute myeloid leukemia (AML) is a common hematopoietic tumor with extremely high morbidity and mortality. This study was designed to explore candidate genes that were related to the poor prognosis of AML patients and analyze their relationship with drug sensitivity. Methods: Microarray databases were performed to screen the differential...
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Modelling Adherence to the Treatment of Cervical Cancer
Enrique Martinez Muñoz,
Maria Luisa Quintero-Soto,
Jorge Hernandez-Valdes,
Javier Carreon-Guillen,
Cruz Garcia-Lirios
Issue:
Volume 9, Issue 4, December 2021
Pages:
191-195
Received:
15 February 2021
Accepted:
21 June 2021
Published:
24 December 2021
Abstract: Background. Cancer Cerval Uterine is a disease That Explains the vulnerability in Which women are in reproductive health With an impact on occupational health and public health, even When In Mexico the prevalence rate is lower than the other Member Countries OECD, ITS impact on Human Development and Local Development shows the Importance That the disease has on Communities rather than in cities Where policies of prevention through screening and medical examination seemed to slow the trend but show a lack Opportunities and capabilities of health centers in rural areas. Objective. Establish the reliability, validity and correlations Between variables Reported in the literature Regarding ITS weighting in a public hospital. Method. A non-experimental, cross-sectional and exploratory study with a nonrandom selection of 104 Patients from a public hospital in the State of Mexico was held. Scale Variables psychosocial determinants of treatment adherence Uterine Cervical Cancer built. Results. From a structural model [χ2 = 490.330 (28 gl) p = 0.000; GFI = 0.927; CFI = 0.970; RMSEA = 0,003]se Showed relationships in adjustment paths Determining Which Had an impact on knowledge treatment adherence behavior (β = 0.50). Conclusion. the boundaries of design, sampling and analysis of the study are noted and recommended to include organizational and psychological variables supported in theories of Organizations and theories of personality.
Abstract: Background. Cancer Cerval Uterine is a disease That Explains the vulnerability in Which women are in reproductive health With an impact on occupational health and public health, even When In Mexico the prevalence rate is lower than the other Member Countries OECD, ITS impact on Human Development and Local Development shows the Importance That the d...
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Neuroendocrine Tumours of Gastrointestinal Tract: Our Experience
Paul Eduardo Lada,
Casares Gonzalo,
Mariot Daniela,
Janikow Christian,
Saliba Jorge,
Martínez Julián,
Santiago Carrizo,
Abril Giménez,
Francisco Flórez
Issue:
Volume 9, Issue 4, December 2021
Pages:
196-201
Received:
10 January 2021
Accepted:
18 January 2021
Published:
24 December 2021
Abstract: Background: TNE-GEPs are rare and originate in the endocrine system located in the gastrointestinal tract (carcinoids) and in the pancreas (island tumours) with a variety of clinical presentations. Design: Cooperative, retrospective. Method: Between January 2005 and December 2018, a cooperative work in the Central Guard Service of the HNC, General Surgery Service "Pablo Luis Mirizzi" of the HNC and Caraffa Private Clinic, 24 patients with TNE-GEP were surgically intervened. Of the total, 14 belonged to the female sex (58.3%) and the remaining 10 men (41.6%), with an age range between 20 and 82 years of age with an average of 55.3 years. Results: The locations were 4 stomachs (16.6%), 14 in the intestine (58.3%) and finally 6 in the head of the pancreas (25%). In relation to the stomach in the 4 patients a total gastrectomy was performed and the pathological anatomy in three demonstrated low-grade neuroendocrine carcinoma and the fourth high degree, the latter dying. 5 patients with clinical presentations of acute appendicitis. The pathological anatomy was further acute appendicitis, a low-grade neuroendocrine carcinoma. In ileum-cecal region, four of it performed right colectomy. In three were low-grade living and fourth high-grade carcinoma with liver mtts who died. In three of the ileum all were occlusive, carrying out intestinal resections, in two low- and last-grade moderate-grade carcinomas with living liver mtts. The colon tumours were, one ascending with hepatic mtts and right colectomy more liver resections, with pathological anatomy being high-grade carcinoma and another a low-grade descending colon. The 6 pancreas lesions, 3 were non-functioning and three other functioning. All patients were operated of CPD. Conclusion: TNE-GEP is a rare pathology but whose frequency is constant onset. With improved imaging methods, we are faced with an increase in preoperative presumption and in the face of its best oncological possibilities, a pathology that every surgeon must know and think about.
Abstract: Background: TNE-GEPs are rare and originate in the endocrine system located in the gastrointestinal tract (carcinoids) and in the pancreas (island tumours) with a variety of clinical presentations. Design: Cooperative, retrospective. Method: Between January 2005 and December 2018, a cooperative work in the Central Guard Service of the HNC, General ...
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Radiobiological Aspects in Determination of Residual Normal Tissue Tolerance Doses for Various Re-irradiation Scenarios
Pavol Matula,
Jan Koncik,
Martin Jasencak
Issue:
Volume 9, Issue 4, December 2021
Pages:
202-208
Received:
31 October 2021
Accepted:
19 November 2021
Published:
29 December 2021
Abstract: Introduction. The current state of re-irradiation in radiation oncology is characterized by the high heterogeneity of re-irradiation practices between institutions. The implementation of imaging methods and new irradiation techniques has created scope for the development and application of more accurate re-irradiation procedures associated with the use of radiobiological modelling, that are allowing often the replacement of palliative intent by radical. Therefore, the preparation of a planning protocol for re-irradiation is a significantly more complex process than for primary treatment planning. It requires quantified dose-volume records from primary and second series, radiobiological knowledge of the regeneration capacity of organs at risk (OaR) and using an appropriate SW-tool for modelling tumour control probability (TCP) versus normal tissue complication probability (NTCP) from individual DVH and pause between series taking into account significant differences in OaR regeneration capacity. Significant restoration takes place within 3-6 months e.g. in the skin, spinal, cord, brain, brain stem and lungs. Other tissues, e.g. kidneys, heart, bladder, have only a small regenerative capacity. This knowledge should be included in the process of preparing a re-irradiation protocol for an individual patient. Purpose: In this contribution we present - an overview of residual tolerance doses for selected OaR in the measure% EQD2cum (biologically equivalent dose of 2 Gy in percents) for 15 - the most critical OaR extirped from retrospective studies (e.g.%EQD2cum for brain stem, spin cord and bladder are 170%, 140%, 125%, respectively). Material and methods: A description of simultaneous determination of residual doses in re-irradiation with an original OaR regeneration model (REGpause) by the authors of paper included into the calculation of the normal tissue complication probability (NTCP) for individual irradiation scenarios of re-irradiation using the “BioGray” program developed in the workplace of authors. Results: A demonstration of the benefits of the tumour control probability (TCP) versus NTCP prediction depending on the location and volume of the clinical tumour volume (CTV) in the primary and second series. Conclusion: The use of the methodology of radiobiological modelling brings a shift from paradigm of verbalism and estimations in the management of re-irradiation to quantitative evaluation of these processes and utilization of translation research knowledge linked to the current technological possibilities of application IMRT, VMAT, SRS/SBRT and proton therapy.
Abstract: Introduction. The current state of re-irradiation in radiation oncology is characterized by the high heterogeneity of re-irradiation practices between institutions. The implementation of imaging methods and new irradiation techniques has created scope for the development and application of more accurate re-irradiation procedures associated with the...
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Giant Cell Tumor of the Distal Tibia and Fibula (Rare Location)
Issue:
Volume 9, Issue 4, December 2021
Pages:
209-212
Received:
22 September 2021
Accepted:
17 December 2021
Published:
31 December 2021
Abstract: Giant cell tumor of the distal tibia is a rare, benign and usually asymptomatic condition. The discovery is sometimes made following a medical imaging examination or a painful symptom or more often a visible or palpable swelling with or without vascular and/or nerve compression. At an advanced stage, the X-ray is of paramount importance. The well complete surgical resection is part of the therapeutic. We present a clinical case report of a young man with a giant cell tumor localized in the distal tibia in Khartoum, Sudan. This case concerns a 37-year-old patient who presented in July 2021 of a huge painful swelling at left distal tibia treated with bonesetter at Kassla, eastern Sudan and whose X-ray radiography showed lytic lesion of the cortical bone in the lower third of the tibia. After the operative resection of the tumor mass, the pathological examination of the operative specimen revealed the diagnosis of a giant cell tumor. A giant cell tumor is a benign condition, with a few symptoms and the location at the ankle is exceptional. Complete surgical resection is a viable treatment option.
Abstract: Giant cell tumor of the distal tibia is a rare, benign and usually asymptomatic condition. The discovery is sometimes made following a medical imaging examination or a painful symptom or more often a visible or palpable swelling with or without vascular and/or nerve compression. At an advanced stage, the X-ray is of paramount importance. The well c...
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