Cancer Research Journal

Volume 7, Issue 3, September 2019

  • Factors Associated with Clinical Outcomes of Differentiated Thyroid Cancer Following Radioiodine Therapy in Tanzania

    Lulu Lunogelo Sakafu, Teddy Frank Mselle, Julius David Mwaiselage, Khamza Kibwana Maunda, Katherine Van Loon, Bouyoucef Salah Eddin

    Issue: Volume 7, Issue 3, September 2019
    Pages: 73-78
    Received: 3 June 2019
    Accepted: 2 July 2019
    Published: 23 July 2019
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    Abstract: Background: Thyroid cancer is the most common endocrine type of malignancy, accounting for 1-5% of all cancers worldwide. Most of the differentiated thyroid cancers are asymptomatic. Surgery is the mainstay of management to be followed by radioactive iodine (RAI). RAI accessibility is still a challenge in most developing countries including Tanzani... Show More
  • Prevalence of Germline Brca1 and Brca2 Mutation Among Filipinos

    Francisco Tria IV, Daphne Ang, Jose Jasper Andal, Frances Victoria Que, Loraine Kay Cabral, Rosil Dimalibot, Rachelle Arah Salamat, Ma. Luisa Enriquez, Sharlynne Bandales, Raymundo Lo, Manuelito Madrid, Marcelo Imasa, Rubi Li

    Issue: Volume 7, Issue 3, September 2019
    Pages: 79-86
    Received: 6 July 2019
    Accepted: 25 July 2019
    Published: 10 August 2019
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    Abstract: The presence of germline mutations in the BRCA1 or BRCA2 tumor suppressor genes are strong predictors of breast or ovarian cancer risk. Loss of the wild-type allele of BRCA1 or BRCA2 genes are required for tumorigenesis. This study identified and characterized the germline BRCA1 and BRCA2 mutation spectrum among Filipinos using Next Generation Sequ... Show More
  • Molecular Mechanisms Associated with Virus-induced Oncogenesis and Oncolysis

    Ram Kumar, Riyesh Thachamvally, Sunil Maherchandani, Bhupendra Nath Tripathi, Sanjay Barua, Naveen Kumar

    Issue: Volume 7, Issue 3, September 2019
    Pages: 87-100
    Received: 4 June 2019
    Accepted: 13 July 2019
    Published: 15 August 2019
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    Abstract: Cancer is a leading cause of human deaths worldwide. Besides inherited genetic disorders, a diverse range of physical, chemical and biological agents may induce cancer. About 15-20% of cancers are known to be originated due to pathogens. Viruses are considered to be the second (after smoking) most important risk factor in inducing human cancer. Vir... Show More
  • Treatment of Patients with Glioblastomas by Low Concentrations of Verapamil Hydrochloride in the Late Postoperative Period

    Nina Gridina, Anatoliy Morozov, Yuriy Ushenin, Vladimir Rozumenko, Nataliya Draguntsova

    Issue: Volume 7, Issue 3, September 2019
    Pages: 101-105
    Received: 5 July 2019
    Accepted: 12 August 2019
    Published: 23 August 2019
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    Abstract: Antitumor effect of calcium channel blockers low concentrations has been investigated on the example of verapamil hydrochloride in the combined treatment of patients with glioblastomas after operation. Patients, who underwent brain tumor surgery, postoperative radiotherapy and chemotherapy, were divided into two groups. The first group of 11 patien... Show More
  • Anti-cancer Immunotherapy Epitope-peptides Vaccination in Patients with Refractory/Persistent Disease of Cervical Cancer and Ovarian Cancer (Phase 1 Studies)

    Satoshi Takeuchi, Tadahiro Shoji, Masahiro Kagabu, Tatsuya Honda Tatsuya Honda, Tadayuki Nagasawa, Yukari Nitta, Toru Sugiyama, Sachiko Yoshimura, Yusuke Nakamura

    Issue: Volume 7, Issue 3, September 2019
    Pages: 106-116
    Received: 1 August 2019
    Accepted: 11 September 2019
    Published: 24 September 2019
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    Abstract: Despite the improvement of treatments, refractory or chemotherapy resistant ovarian and cervical cancers have been still incurable. In such tumors, the actionable salvage gene-pathways of up-regulating lung cancer 10 (URLC10), hypoxia inducible factor (HIF) and its core protein HIG2- tumor growth factor beta (TGF beta)- the Caenorhabditis elegans S... Show More
  • High Expression of C-reactive Protein Increases the Risk of Poor Prognosis in Patients with Gastric Cancer: A Meta-analysis

    Fulun Li, Ke Liu, Qianlong Zhao, Junyi Chen, Lingfei Liu, Qing-Mu Xie, Jing Yang

    Issue: Volume 7, Issue 3, September 2019
    Pages: 117-124
    Received: 27 August 2019
    Accepted: 10 September 2019
    Published: 24 September 2019
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    Abstract: There are many researches on the correlation between C-reactive protein (CRP) and prognosis of gastric cancer, but whether CRP could be used as an evaluation indicator for prognosis of gastric cancer patients, which was still controversial. Therefore, we conducted meta-analysis based on 18 studies involving 3656 objects. The results show that, CRP ... Show More