Cancer Research Journal

Volume 8, Issue 4, December 2020

  • Malignant Ovarian Germ Cell Tumors in Pediatric Age Group: A Clinicopathological Study over 21 Years in Eastern Rajasthan (India)

    Rajendra Kumar Tanwar, Bharti Saxena, Shankar Lal Mohanpuria, Harsh Goyal, Laxmi Agarwal, Madhu Saxena, Man Mohan Agarwal

    Issue: Volume 8, Issue 4, December 2020
    Pages: 57-61
    Received: Aug. 18, 2020
    Accepted: Sep. 03, 2020
    Published: Oct. 27, 2020
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    Abstract: Background: The aim of this study is to analyze the clinicopathological features, diagnosis and treatment outcome of rare cases of malignant ovarian germ cell tumors in a government tertiary care hospital centre keeping fertility preservation surgery as a goal in young girls below 21 years of age. Methods: This is a retrospective study comprising o... Show More
  • Primitive Neuroectodermal Tumor of Cervix: Report of a Rare Case and Review of Literature

    Rajendra Kumar Tanwar, Bharti Saxena, Harsh Goyal, Shagufta Siddiqui, Rakesh Kumar Singh, Ravindra Singh Gothwal, Madhu Saxena

    Issue: Volume 8, Issue 4, December 2020
    Pages: 62-67
    Received: Oct. 25, 2020
    Accepted: Nov. 05, 2020
    Published: Nov. 16, 2020
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    Abstract: Background – Primitive neurocetodermal tumor / Ewing’s sarcoma (PNET/ES) of uterine cervix is extremely rare tumor and only 27 cases have so far been reported in the literature. We hereby present one case report diagnosed by histopathology and IHC and review of literature. Objective –A young girl aged 20 years was admitted. Her routine investigatio... Show More
  • Identification of 11 Differentially Expressed Hub Genes and Their Upstream microRNAs in Nasal-type NK/T-cell Lymphoma Based on Clinical Sample Analysis

    Daxia Cai, Ying Yang, Zewei Jiang, Dongmei He

    Issue: Volume 8, Issue 4, December 2020
    Pages: 68-81
    Received: Oct. 27, 2020
    Accepted: Nov. 13, 2020
    Published: Nov. 23, 2020
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    Abstract: Nasal-type NK/T-cell lymphoma (nasal-type NKTL) is one of the most lethal cancers for. Our study aimed to identify hub differentially expressed genes (DE- genes) and their upstream microRNAs between nasal-type NK/T-cell lymphoma (NKTL) tumor samples and normal nasal tissues through integrated bioinformatics. The 503 DE-genes and 106 DE-miRNAs were ... Show More
  • FKBPL Is a Potential Prognostic Biomarker and Correlated with Immune Infiltrates and T Cells Exhaustion in Hepatocellular Carcinoma

    Feng Tian, Lifu Wang, Baiqiang Ma, Bingzhen Li, Daxia Cai

    Issue: Volume 8, Issue 4, December 2020
    Pages: 82-93
    Received: Nov. 11, 2020
    Accepted: Nov. 20, 2020
    Published: Nov. 27, 2020
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    Abstract: Hepatocellular carcinoma (HCC) is a malignant tumor with high mortality and poor prognosis. And FKBPL plays a crucial role on the development of cancers. This study aims to explore the prognostic potential of FKBPL and comprehensively analyze the correlations between FKBPL, immune infiltration, and T cells function in HCC. GEO database, Oncomine da... Show More
  • Precancerous Cervical Lesion Among Women in Public Hospitals of Addis Ababa, Ethiopia

    Tesfay Temesgen, Girmay Adhena, Zerihun Figa

    Issue: Volume 8, Issue 4, December 2020
    Pages: 94-99
    Received: Sep. 01, 2020
    Accepted: Sep. 19, 2020
    Published: Dec. 16, 2020
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    Abstract: Background: Cervical cancer is one of the leading causes of death among women in the world and particularly in Africa. Countries of the glob adopted proven the importance of precancerous lesion screening. However, cervical cancer remains one of the leading causes of cancer morbidity and mortality in sub-Saharan Africa including Ethiopia. This study... Show More
  • Castleman Disease in Children from Histopathology to Therapy

    Asmaa Hamoda, Hanaa Rashad, Ola Ahmad, Hala Reda, Iman Zaki, Naglaa Elkinaai, Mohamed Sedki, Alaa El Hadad, Samah Semary

    Issue: Volume 8, Issue 4, December 2020
    Pages: 100-103
    Received: Apr. 11, 2020
    Accepted: Dec. 15, 2020
    Published: Dec. 22, 2020
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    Abstract: Background: Castleman disease (CD) describes a group of rare lymphoproliferative disorder with characteristic histopathology. It presents with heterogeneous clinical features whether unicentric (UC) or multicentric disease (MCD). The aim of the work was to describe clinic-pathological characteristics, management and outcome of different types of ca... Show More